Frontiers in Immunology
July 14, 2015
Attila Szabo
153 citations
Classical psychedelics are psychoactive substances, which, besides their psychopharmacological activity, have also been shown to exert significant modulatory effects on immune responses by altering signaling pathways involved in inflammation, cellular proliferation, and cell survival via activating NF-κB and mitogen-activated protein kinases. Recently, several neurotransmitter receptors...
The Lancet
July 4, 2015
Willem Kuyken, Rachel Hayes, B. Barrett et al.
BACKGROUND Individuals with a history of recurrent depression have a high risk of repeated depressive relapse or recurrence. Maintenance antidepressants for at least 2 years is the current recommended treatment, but many individuals are interested in alternatives to medication. Mindfulness-based cognitive therapy (MBCT) has been shown to reduce risk of relapse or recurrence compared with usual...
Comprehensive Psychiatry
July 2015
F Fagioli, L Telesforo, A Dell'Erba et al.
"Depersonalization" (DP) is a common symptom in the general population and psychiatric patients (Michal et al., 2011 [1]). DP is characterized by an alteration in the experience of the self, so that one feels detached from his or her own mental processes or body (or from the world), feeling as being an outside observer of his or her own self, and loosing the experience of unity and identity...
Biological Psychiatry
July 1, 2015
Carlos A. Zarate, Rodrigo Machado‐Vieira
Studies that evaluate agents with potentially rapid antidepres-sant effects are critical to developing new, improved treat-ments for major mood disorders. In particular, such studiesmay offer key insights into the mechanism of action of rapid-acting antidepressants as well as the neurobiology of mooddisorders (1). In their excellent article published in this issue ofBiological Psychiatry,...
Psychology and Psychotherapy Theory Research and Practice
June 27, 2015
Nicole P. Kearns, Frances Shawyer, Joanne Brooker et al.
38 citations
OBJECTIVES: Major depressive disorder is a significant mental illness that is highly likely to recur, particularly after three or more previous episodes. Increased mindfulness and decreased rumination have both been associated with decreased depressive relapse. The aim of this study was to investigate whether rumination mediates the relationship between mindfulness and depressive relapse....
Applied Psychophysiology and Biofeedback
June 25, 2015
Judith Esi van der Zwan, Wieke de Vente, Anja C. Huizink et al.
321 citations
In contemporary western societies stress is highly prevalent, therefore the need for stress-reducing methods is great. This randomized controlled trial compared the efficacy of self-help physical activity (PA), mindfulness meditation (MM), and heart rate variability biofeedback (HRV-BF) in reducing stress and its related symptoms. We randomly allocated 126 participants to PA, MM, or HRV-BF upon...
Proceedings of the National Academy of Sciences
June 8, 2015
Manabu Fuchikami, Alexandra M. Thomas, Rongjian Liu et al.
282 citations
Ketamine produces rapid and sustained antidepressant actions in depressed patients, but the precise cellular mechanisms underlying these effects have not been identified. Here we determined if modulation of neuronal activity in the infralimbic prefrontal cortex (IL-PFC) underlies the antidepressant and anxiolytic actions of ketamine. We found that neuronal inactivation of the IL-PFC completely...
June 5, 2015
Bahram Iranshahri, H. Jenaabadi
The present study aimed to examine the effectiveness of mindfulness therapy in controlling under treatment addicts’ drug cravings. This was a quasi-experimental study with pretest and posttest. The sample of this study included 30 under treatment male addicts whom were selected through applying random sampling method and were placed in two groups, experimental and control. After holding a...
European Psychiatry
June 1, 2015
G.-F. Zhang, W.-X. Liu, L.-L. Qiu et al.
Abstract: Current available antidepressants exhibit low remission rate with a long response lag time. Growing evidence has demonstrated acute sub-anesthetic dose of ketamine exerts rapid, robust, and lasting antidepressant effects. However, a long term use of ketamine tends to elicit its adverse reactions. The present study aimed to investigate the antidepressant-like effects of intermittent...
Journal of cross-cultural gerontology
June 1, 2015
Sulim Lee, Soyoung Choun, Carolyn M. Aldwin et al.
Whether wisdom is a culturally-specific or universal construct is a matter of some debate (see Curnow 1999; Grossman et al. Psychological Science, 2012). This study compared similarities and differences in the factor structure of a measure of wisdom focused on self-transcendence in U.S. (n = 305, M(age) = 33.99) and Korean samples (n = 838, M(age) = 30.28), with ages ranging from 20 to 73). The...