\n Alucinógenos (ALU) são substâncias psicoativas que não induzem o indivíduo à dependência, possuem perfil de segurança de uso mais alto quando comparado a outras drogas e baixa capacidade de causar tolerância ao uso. Estudos recentes propõem o uso de ALU como tratamento a algumas doenças e transtornos relacionados ao sistema nervoso central, como a depressão, ansiedade e dependência. Dentre...
medRxivDecember 12, 2019Ron Shore, Paul Ioudovski, Craig Goldie et al.8 citations
preprint
Abstract We conducted a scoping review on psilocybin-assisted therapy for addiction, depression, anxiety and post-traumatic stress disorder. Psilocybin is a naturally-occurring tryptophan derivative found in species of mushroom with psycho-active properties. From 2022 records identified by database searching, 40 publications were included in the qualitative synthesis from which we identified 9...
This pre-post, single-centered study evaluates the effects of a compassion-oriented mindfulness-based intervention on health professionals’ quality of life. The intervention was conducted in an Italian general hospital in the province of Milan. Between 2014 and 2015, thirty-four health professionals operating in the territorial psychiatric services followed an 18-week Compassion-Oriented...
Abstract Rationale 5-methoxy-N,N-dimethyltryptamine is a psychotropic substance found in various plant and animal species and is synthetically produced. 5-methoxy-N,N-dimethyltryptamine is used in naturalistic settings for spiritual exploration, recreation, or to address negative affect and mood problems. However, scientific knowledge on the effects of 5- methoxy-N,N-dimethyltryptamine in...
Clinical and preclinical studies have demonstrated that depression, one of the most common psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF), contributing to neuronal atrophy in the prefrontal cortex (PFC) and hippocampus, and reduced hippocampal adult neurogenesis....
Clinical and preclinical researches have shown that sub-anesthetic ketamine elicits sustained antidepressant effects for up to 1-2 weeks. Pharmacokinetics studies (t1/2 = 23 min) in mice showed no ketamine residue at 24 h after sub-anesthetic or anesthetic ketamine administration. Therefore, this study aims to reveal the mechanism underlying these different biological functions at 24 h after...
Molecular PsychiatryDecember 2019Nathan H Wray, Jeffrey M Schappi, Harinder Singh et al.
Ketamine produces rapid and robust antidepressant effects in depressed patients within hours of administration, often when traditional antidepressant compounds have failed to alleviate symptoms. We hypothesized that ketamine would translocate Gαs from lipid rafts to non-raft microdomains, similarly to other antidepressants but with a distinct, abbreviated treatment duration. C6 glioma cells...
Purpose Substance abuse has become a major health issue in Thailand, contributing to high numbers of premature deaths and requiring considerable expenditure on treatment and rehabilitation programs. The purpose of this paper is to explore use of Vipassana meditation to reduce depression and improve empathy and self-awareness in drug dependent women at a rehabilitation centre....
Starting around 2009, online communities envisioned and began practicing “tulpamancy”—the ability to imagine a sentient being, or “tulpa,” into existence through heightened states of imagination. Originating in Tibetan Buddhist mysticism and contemporary paranormal lore, online users create tulpas, which they sense as a distinct personality within their minds and bodies, for companionship....
Abstract Background Psychedelic microdosing is the trending practice of using tiny repeated doses of psychedelic substances to facilitate a range of supposed benefits. With only a few published studies to date, the subject is still under-researched, and more knowledge is warranted. Social media and internet discussion forums have played a vital role in the growing visibility of the microdosing...