Zaburzenia depresyjne są jednymi z najczęściej występujących chorób psychicznych na świecie. Leczenie depresji stanowi ważny problem medyczny, a strategie farmakologiczne oparte na wyrównywaniu zaburzeń transmisji monoaminergicznych w mózgu wiążą się z opóźnionym w czasie efektem przeciwdepresyjnym. Ponadto, coraz większy odsetek pacjentów cierpi na depresję lekooporną, gdzie pomimo wdrożenia...
Ketamine has emerged as one of the most promising therapies for treatment-resistant depression. However, inter-individual variability in response to ketamine is still not well understood and it is unclear how ketamine's molecular mechanisms connect to its neural and behavioral effects. We conducted a single-blind placebo-controlled study, with participants blinded to their treatment condition....
The default mode network (DMN) is intricately linked with processes such as self-referential thinking, episodic memory recall, self-projection, and understanding the mindset of others. Over recent years, there has been a surge in examining its functional connectivity, particularly its antagonistic relationship with frontoparietal networks (FPN) involved in top-down attention, executive...
Background: Reference to an intrinsic healing mechanism or an ‘inner healer’ is commonplace amongst psychedelic drug-using cultures. The ‘inner healer’ refers to the belief that psychedelic compounds, plants or concoctions have an intrinsically regenerative action on the mind and brain, analogous to intrinsic healing mechanisms within the physical body, for example, after sickness or injury....
Introduction: Yoga combines asanas (postures), pranayamas (breathing exercises), and dhyanas (meditation) to improve physical and mental well-being. It's recognized for its substantial health benefits, safety, and cost-effectiveness, leading to calls for its broader integration into healthcare for its therapeutic and preventative potential. This study aims to explore yoga's multifaceted health...
Importance Psilocybin has been studied in the treatment of depression and anxiety disorders. Clinical studies have mainly focused on efficacy, with systematic reviews showing favorable efficacy; however, none have primarily focused on psilocybin safety. Objective To evaluate the acute adverse effects of psilocybin at therapeutic doses in the treatment of depression and anxiety. Data Sources...
Who will staff the psychedelic resurgence? Erika Dyck, Professor and Canada Research Chair in History of Health & Social Justice from the University of Saskatchewan, provides an intriguing answer to this question. On 6th February 2024, a research team at Le Grau-du-Roi Hospital in the south of France, led by addictologist Amandine Luquiens, put their first subject through a clinical trial with...
Psilocybin, and its metabolite psilocin, induces psychedelic effects through activation of the 5-HT2A receptor. Psilocybin has been proposed as a treatment for depression and anxiety but sometimes induces anxiety in humans. An understanding of mechanisms underlying the anxiety response will help to better develop therapeutic prospects of psychedelics. In the current study, psilocybin induced an...
3,4-methylenedioxy-methamphetamine (MDMA) is a synthetic drug very similar to hallucinogens and stimulants. This drug is also called ecstasy or molly. It produces feelings of pleasure, warmth, distorted sensory time and perception. MDMA increases the activity of serotonin, dopamine and norepinephrine in the brain. It causes various health effects such as nausea, sweating, chills, muscle...
BackgroundChronic cancer-related pain (CRP) can have a significant negative impact on quality of life. Mindfulness is hypothesized to mitigate chronic CRP by regulating both physical and emotional resistance to pain. In recent years, there has been interest in the use of virtual reality (VR) to deliver mindfulness meditation. VR provides an immersive and engaging environment, which may enhance...