Psychedelic compounds continue gaining scientific and regulatory traction as potential new treatments for psychiatric disorders. While most psychiatrists will likely not work directly with these compounds, psychedelic research practices provide insights that may improve conventional psychiatric care. Through its emphasis on 'set and setting' (mindset and environment, respectively), psychedelic...
Epilepsia openDecember 1, 2024Samantha Weber, Johannes Jungilligens, Selma Aybek et al.7 citations
Dissociative seizures are paroxysmal disruptions of awareness and behavioral control in the context of affective arousal. Alterations in stress-related endocrine function have been demonstrated, but the timescale of dissociation suggests that the central locus coeruleus (LC) noradrenergic system is likely pivotal. Here, we investigate whether LC activation at rest is associated with altered...
Work and family role conflict is a common source of stressors that affect nurses, leading to negative outcomes on their mental health, such as depressive symptoms, which affect nurses' job performance and patients' health outcomes. Mindfulness positively affected mental health, but its role in the relationship between role conflict and depressive symptoms was not previously examined. To examine...
Dyspnea and cough are frequent symptoms in ILD patients. The management of these symptoms is challenging, and evidence-based therapies are lacking. To evaluate the effect of an online Mindfulness-Based Intervention (eMBI) on reducing dyspnea in patients affected by different ILDs. This study was a prospective, open-label, controlled trial that included patients ≥18 years and a modified Medical...
Introduction: Chronic headache is one of the most common health issues leading to long-term disability, which results not only in a decline in the quality of life but also increases depressive and anxiety-related symptoms. In the case of chronic pain, the effectiveness of acute pain relief is limited. International research increasingly highlights the importance of modifying psychological and...
Mantra recitation has been shown to improve emotional well-being in neurotypical individuals with mental health conditions; however, no research has explored its effect on the autistic population. The private, routine nature of mantra and mantra-like recitation may offer unique advantages for autistic individuals struggling with negative emotions and emotion regulation. The purpose of this...
Prenatal mindfulness programs can improve mental health, yet access to and cultural and linguistic relevance of existing programs in the United States are limited for people who do not speak English and/or face major life stressors such as migration, housing instability, limited income, and racism. In response, mindfulness skills training drawn from Mindfulness-Based Childbirth and Parenting...
In this review, we discuss psychedelics' acute subjective and persisting therapeutic effects, outline the science of positive emotions, and highlight the value in considering distinct positive emotions in psychedelic science. Psychedelics produce a wide variety of acute subjective effects (i.e. the 'trip'), including positive emotions and affective states such as awe and joy. However, despite a...
The emerging antidepressant effects of ketamine have inspired tremendous interest in its underlying neurobiological mechanisms, although the involvement of 5-HT in the antidepressant effects of ketamine remains unclear. The chronic restraint stress procedure was performed to induce depression-like behaviours in mice. OFT, FST, TST, and NSFT tests were used to evaluate the antidepressant-like...
Psychopharmacotherapy of major psychiatric disorders is mostly based on drugs that modulate serotonergic, dopaminergic, or noradrenergic neurotransmission, either by inhibiting their reuptake or by acting as agonists or antagonists on specific monoamine receptors. The effectiveness of this approach is limited by a significant delay in the therapeutic mechanism and self-perpetuating growth of...