Applied Family Therapy Journal
2020
SeyedAliAsghar SeyedEbrahimi
Aim: The purpose of this research is the effectiveness of cognitive therapy based on mindfulness and positive thinking on improving mental health, perfectionism and cognitive emotion regulation strategies in family heads suffering from major depressive disorder. Method: The research method was semi-experimental with a pre-test-post-test design and follow-up with the control group. The...
Therapeutic Advances in Psychopharmacology
2020
Marcos Gómez‐revuelta, María Fernández-Rodríguez, Laura Boada-Antón et al.
Ketamine’s pharmacological profile makes it an interesting and useful drug to challenge treatment-resistant-depression (TRD). Emerging adverse events associated with single-slow-sub-anaesthetic doses for the treatment of depression are common, although generally transient and self-limited. Nevertheless, data on the safety of this practice are scarce. Thus, it seems timely before ketamine is...
Epidemiology and Psychiatric Sciences
2020
Chiara Gastaldon, D. Papola, G. Ostuzzi et al.
Abstract In March 2019, the US Food and Drug Administration (FDA) approved a nasal spray formulation of esketamine for the treatment of resistant depression in adults. Esketamine is the S-enantiomer of ketamine, an FDA-approved anaesthetic, known to cause dissociation and, occasionally, hallucinations. While ketamine has not been approved for depression in the USA or in any other country, it...
Advances in pharmacology (San Diego, Calif.)
2020
Lynnette A. Averill, Samar Fouda, James W. Murrough et al.
A paradigm shift in the conceptualization of the neurobiology of depression and the serendipitous discovery of ketamine's rapid-acting antidepressant (RAAD) effects has ushered in a new era of innovative research and novel drug development. Since the initial discovery of ketamine's RAAD effects, multiple studies have supported its short-term efficacy for fast-tracked improvements in...
Transpersonal Psychology Review
2020
Scott Buckler, April Woodward
A proposed direction for transpersonal psychology is the development of empirical research within the field, specifically in assessing the effects of transpersonal practices. The areas of self-actualisation, peak experience and flow have been subjected to research predominantly using psychometrics, however a range of theoretical and methodological issues within these concepts are evident. An...
Therapeutic advances in drug safety
2020
Mohammed S Salahudeen, Cameron M Wright, Gregory M Peterson
This narrative review aims to provide an overview of the current literature on the pharmacology, safety, efficacy and tolerability of intranasal esketamine, the S-enantiomer of ketamine, for the treatment of treatment-resistant depression (TRD). A literature search using Medline, Embase, PsycINFO and Cochrane Central was conducted (January 2000 to July 2019). Product information and...
Therapeutic Advances in Psychopharmacology
2020
Paul Glue, Natalie J. Medlicott, Shona Neehoff et al.
43 citations
Background: Ketamine’s defining side effects are dissociation and increased blood pressure/heart rate. An oral formulation with delayed absorption could minimize these effects. We recently reported safety and tolerability data for an extended release ketamine tablet in healthy volunteers. Methods: To assess safety, tolerability, efficacy, and pharmacokinetics of an extended release oral...
Journal of Contextual Behavioral Science
2020
Jordan Sloshower, Jeffrey Guss, Robert Krause et al.
168 citations
Abstract Psychedelic-assisted therapy is based on the premise that psychedelic substances can act as catalysts or adjuncts to psychotherapeutic processes. Recent clinical trials involving psychedelic-assisted therapy have generally employed a similar three-part structure consisting of preparation, support during the dosing sessions, and subsequent “integration.” However, the content of these...
Journal of Affective Disorders
2020
Roman M. Dale, Kelly A. Bryant, Nora Finnegan et al.
17 citations
There are many putative mechanisms by which ketamine has its effect and many unanswered questions about risks and benefits of long-term ketamine therapy. A research imperative is the identification of predictors of response to intravenous ketamine, especially a sustained response to maintenance ketamine. Temperament is an inherited aspect of personality and is a predictive factor for outcome in...
Therapeutic Advances in Psychopharmacology
2020
Kim P. C. Kuypers
83 citations
Microdosing psychedelics is the repeated use of small doses of, for example, lysergic acid diethylamide (LSD) and psilocybin, typically for a few weeks. Despite the popular and scientific attention in recent years, and claims by users that it has therapeutic value in affective disorders like depression, little scientific knowledge is available to back this. The purpose of this review was to...