Mundo Amazónico
2020
Jimmy Weiskopf
1 citation
This is the final episode of a three-part story about a visit to Iquitos at the time of the new millennium by the narrator, who lives in Colombia and has been drinking yajé (ayahuasca) with its indigenous shamans. For a book he is writing about the subject, decides to investigate its uses in Iquitos, where his host and guide to the rituals there is “Zappa”, an American expatriate who exports...
Current Medicinal Chemistry
December 13, 2019
Genís Ona, José Carlos Bouso
15 citations
In the drug development, the formation of highly selective ligands has been unsuccessful in the treatment of central nervous system disorders. Multi-target ligands, from the polypharmacology paradigm, are being proposed as treatments for these complex disorders, since they offer enhanced efficacy and a strong safety profile. Natural products are the best examples of multi-target compounds, so...
Clinical Toxicology
October 1, 2019
Chuan-Huai Liu, Wei-Lan Chu, Shu-Chen Liao et al.
10 citations
Introduction: Illicit substance use is an increasing problem all over the world, especially in adolescents and young adults. It is a challenge to make a definitive diagnosis of a specific substance in a poisoning case without toxicology laboratory confirmation. We confirmed the presence of N,N-dimethyltryptamine (DMT) by liquid chromatograph tandem mass spectrometer (LC/MS/MS) in biologic...
Revista de Biologia Neotropical
August 21, 2019
Claudio Mazzatenta
Este estudo foi realizado na cidade de Iquitos (Amazônia peruana), onde a maioria dos curandeiros indígenas usa a bebida psicotrópica ayahuasca, a qual deve seus potentes efeitos principalmente à mistura de duas plantas, Banisteriopsis caapi (Spruce ex Griseb.) C.V. Morton e Psychotria viridis Ruiz & Pav. O brebaje palo é uma bebida psicotrópica alternativa, que provoca efeitos similares aos da...
Drugs Education Prevention and Policy
May 7, 2019
Marc Aixalà, Genís Ona, Òscar Parés et al.
16 citations
In recent years, the use of natural psychoactive drugs (NPDs) has grown rapidly. They are classified as new psychoactive substances (NPSs), despite the reality that they have been used for centuries. We are lacking information regarding patterns of use or characteristics of users, but some evidence suggests that NPDs substantially differ from NPSs in terms of both their safety profile and...
Journal of Psychoactive Drugs
April 25, 2019
Alexandra Vsl Rodrigues, Francisco Almeida, Maria Augusta Vieira‐coelho
30 citations
N, N-dimethyltryptamine (DMT) is an indole alkaloid produced by a number of plants and animals, including humans. Its psychoactive effects were first described in 1956 by Stephen Szára, but have been exploited for centuries by South American indigenous populations in the form of ayahuasca. In the present review, we assess the state of the art regarding a putative role for endogenous DMT and...
International Journal of Psychotherapy Practice and Research
January 2, 2019
Jan M. Keppel Hesselink, Jan M. Keppel Hesselink
Since the 2nd part of last century neo-shamanic rituals using mind-altering extracts from plants or animals have become increasingly popular in Europe and the USA. The first rituals coming to the west were based on drinking a special Amazonian tea, Ayahuasca, based on 2 different plants, with active compounds belonging to the class of the beta-carbolines (harmala alkaloids) and tryptamines. The...
Journal of Psychoactive Drugs
2019
Ilana Berlowitz, Heinrich Walt, Christian Ghasarian et al.
70 citations
Chronic illness management today commonly involves alternative medicines. Substance use disorder (SUD), as a chronic psychosomatic illness, might benefit from a similar approach. The accredited Takiwasi Center offers such an SUD treatment program involving Amazonian medicine combined with psychotherapy. The current study assessed this integrative program's short-term therapeutic effects. We...
2019
17 citations
Researchers, program administrators, and practicing clinicians explain the most recent developments in using psychedelic substances to treat psychological, physiological, and social problems. More than a decade ago, the U.S. government lifted its ban on all testing of psychedelic substances. Winkelman and Sessa now provide updated scientific research and applications of these substances, now...
Plants
August 18, 2018
Carmen X Luzuriaga-Quichimbo, Míriam Hernández del Barco, José Blanco-Salas et al.
This study's objective was to evaluate the rescued traditional knowledge about the chiricaspi (Brunfelsia grandiflora s.l.), obtained in an isolated Canelo-Kichwa Amazonian community in the Pastaza province (Ecuador). This approach demonstrates well the value of biodiversity conservation in an endangered ecoregion. The authors describe the ancestral practices that remain in force today. They...