Journal of Psychoactive Drugs
February 20, 2025
Broc A. Pagni, Andreas Halman, Jerome Sarris et al.
7 citations
The durability of ayahuasca's effects on mental health and the influence of clinical diagnoses on therapeutic response is unclear. Adults with no prior exposure to ayahuasca (n = 66) participating in neo-shamanic ayahuasca ceremonies completed questionnaires at baseline, 7 days, and 1, 6, and 12 months. Mixed models were used to characterize temporal trajectories in mental health, alcohol and...
Psychedelics
December 10, 2024
Lorena Terene Lopes Guerra, Rafael G. Dos Santos, Jaime E. C. Hallak
3 citations
Ayahuasca is a hallucinogenic substance currently being investigated for the treatment of mood, anxiety, and trauma-related disorders. Evidence from animal and human studies suggest that the effects of ayahuasca involve modulation of neural substrates relevant for emotional processing, especially in regions rich in serotonergic receptors. Moreover, preclinical studies also show that ayahuasca...
Brazilian Journal of Health Review
December 3, 2024
Francy Gizella Marroquin Rincon, Rhaiana de Fatima Vidal Gondim, Josana de Castro Peixoto
A ansiedade tem sido um dos principais probelmas de saúde mental na atualidade. Os transtornos de ansiedade afetam milhões de pessoas e que os tratamentos convencionais apresentam limitações, como efeitos colaterais e potenciais de dependência, este estudo busca explorar o potencial terapêutico da ayahuasca no tratamento de transtornos de ansiedade. O objetivo do estudo foi analisar e discutir...
Neuroscience & Biobehavioral Reviews
September 20, 2024
Isabel Werle, Leandro J Bertoglio
17 citations
Threatening events and stressful experiences can lead to maladaptive memories and related behaviors. Existing treatments often fail to address these issues linked to anxiety/stress-related disorders effectively. This review identifies dose ranges associated with specific actions across various psychedelics. We examined psilocybin/psilocin, lysergic acid diethylamide (LSD),...
July 28, 2024
Jonathan David, Aviva Berkovich-Ohana, Yair Dor-Ziderman
2 citations
preprint
Background: How the human psyche interacts with the theme of death is fundamental to individual and societal life, profoundly influencing cognition, affect, and behavior. Death-related psychological phenomena, such as death anxiety and acceptance, have been shown in clinical studies to be influenced by psychedelic (LSD and psilocybin) interventions. However, the literature lacks a comprehensive...
Journal of Pakistan Psychiatric Society
June 30, 2024
Nauman Ashraf
1 citation
Psychedelics, substances known to alter perception, mood, and consciousness, have been used across various cultures for centuries, often in religious ceremonies to facilitate spiritual experiences. Lysergic acid diethylamide (LSD) was used clinically from the 1950s until its ban in 1967. Recently, there has been a resurgence of interest in psychedelics for treating mental health disorders such...
medRxiv
June 20, 2024
Dimy Fluyau, Vasanth Kattalai Kailasam, Neelambika Revadigar
preprint
Abstract Background Hallucinogens attract research as alternatives to the commonly used medications to treat major depressive and anxiety disorders. Aims Assess hallucinogens’ efficacy for managing depressive and anxiety symptoms and evaluate their safety profiles. Method In five databases, we searched for randomized controlled trials of hallucinogens targeting depressive and anxiety symptoms....
May 1, 2024
Banan Ramarushton
Rumination is a well-established risk factor for the onset and maintenance of depression and anxiety and has been identified as a transdiagnostic factor due to its association with multiple forms of psychopathology. A renaissance of psychedelic research shows promise in treating psychopathology with potential for acting on ruminative processes. Despite the growing interest and developments in...
Journal of Ethnopharmacology
February 10, 2024
Tiago Arruda Sanchez, Lucas Rego Ramos, Felipe Araujo et al.
12 citations
Ayahuasca is a beverage used in Amazonian traditional medicine and it has been part of the human experience for millennia as well as other different psychoactive plants. Although Ayahuasca has been proposed as potentially therapeutic as an anxiolytic and antidepressant, whilst no studies have been carried out so far investigating their direct effect on brain emotional processing. This study...
Psychoactives
November 17, 2023
Anna Beatriz Vicentini, Lucas Silva Rodrigues, Giordano Novak Rossi et al.
4 citations
Alcohol is the recreational drug most frequently consumed, and its high frequency of use can lead to worsening social, psychological, and domestic issues. The age group most susceptible to alcohol dependence is 18- to 24-year-old youths, demanding interventional tools to target early involvement risks. Ayahuasca seems to be a promising therapeutic tool since evidence suggests it presents...