Chronic exposure to delta 9-tetrahydrocannabinol fails to irreversibly alter brain cannabinoid receptors.
T M Westlake, A C Howlett, S F Ali, Merle G. Paule, Andrew C. Scallet, William Slikker
Brain Research March 22, 1991 DOI: 10.1016/0006-8993(91)90897-5 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational animal study Peer reviewed |
|---|---|
| Population | Rats chronically treated with delta 9-THC and monkeys chronically exposed to marijuana smoke |
| Interventions | Delta 9-tetrahydrocannabinol (delta 9-THC) Marijuana smoke |
| Topics | Cannabis |
| Key findings | Chronic delta 9-THC exposure in rats and chronic marijuana smoke exposure in monkeys did not appear to irreversibly alter brain cannabinoid receptor properties in the brain regions examined, including the rat striatum, cortex, cerebellum, hippocampus, and brainstem/spinal cord and the monkey caudate, prefrontal cortex, and cerebellum. |
Abstract
The effects of chronic delta 9-tetrahydrocannabinol (delta 9-THC) and marijuana administration on the properties of brain cannabinoid receptor populations of the rat and monkey, respectively, were examined in this study. It was determined that the properties of the cannabinoid receptors in the striatum, cerebral cortex, cerebellum, hippocampus, and brainstem/spinal cord of the rat do not appear to be irreversibly altered by chronic exposure to delta 9-THC. Similarly, the cannabinoid receptors in the caudate, prefrontal cortex, and cerebellum of the monkey do not appear to be irreversibly altered by chronic exposure to marijuana smoke.
Comparable studies
Other preclinical and animal studies on cannabis, most cited first.
Citations in the library
Cited by 4
- Behavioral pharmacology of cannabinoids with a focus on preclinical models for studying reinforcing and dependence-producing properties. Current Drug Abuse Reviews November 2008
- Altered brain tissue composition in heavy marijuana users. Drug and Alcohol Dependence January 7, 2005
- Tolerance to the disruptive effects of Delta(9)-THC on learning in rats. Pharmacology, Biochemistry, and Behavior December 2002
- Chronic marijuana smoke exposure in the rhesus monkey. IV: Neurochemical effects and comparison to acute and chronic exposure to delta-9-tetrahydrocannabinol (THC) in rats. Pharmacology, Biochemistry, and Behavior November 1991
Cites 5
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