Tolerance to the disruptive effects of Delta(9)-THC on learning in rats.
M S Delatte, P J Winsauer, J M Moerschbaecher
Pharmacology, Biochemistry, and Behavior December 2002 DOI: 10.1016/s0091-3057(02)00966-8 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Rats responding under a multiple schedule of repeated acquisition and performance |
| Interventions | Delta(9)-tetrahydrocannabinol (Delta(9)-THC) SR141716A |
| Dose | Delta(9)-THC 1-10 mg/kg acutely and 5.6 mg/kg chronically; SR141716A 0.32 and 1 mg/kg |
| Topics | Cannabis |
| Key findings | Tolerance to Delta(9)-THC's rate-decreasing and error-increasing effects developed in both the acquisition and performance components after daily administration of 5.6 mg/kg. When 1 mg/kg SR141716A was substituted during chronic treatment, it selectively increased within-session errors in the acquisition component, suggesting learning was more sensitive than performance to the antagonist under these conditions. |
Abstract
Tolerance to the effects of the cannabinoid agonist Delta(9)-tetrahydrocannabinol (Delta(9)-THC) was characterized in rats responding under a multiple schedule of repeated acquisition and performance. During the acquisition component, subjects acquired a different three-response sequence each session, whereas in the performance component the sequence was the same each session. Responding was maintained under a second-order fixed-ratio 2 (FR2) schedule of food reinforcement. Acute doses of Delta(9)-THC (1-10 mg/kg) decreased rate and accuracy in both components, whereas doses of the cannabinoid (CB1) receptor antagonist N-(piperidin-1-yn-)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride (SR141716A; 0.32 and 1 mg/kg) were ineffective. While 5.6 mg/kg of Delta(9)-THC disrupted responding when administered acutely, tolerance to the rate-decreasing and error-increasing effects of this dose developed in both components after daily administration. When 1 mg/kg of SR141716A was substituted for Delta(9)-THC during chronic administration, this previously ineffective dose selectively increased within-session errors in the acquisition component of the multiple schedule. During the postchronic phase, subjects were generally less sensitive to the disruptive effects of Delta(9)-THC. In summary, these data demonstrated that tolerance to Delta(9)-THC developed across two different behavioral tasks and that learning was generally more sensitive than performance to the effects of SR141716A during chronic treatment with Delta(9)-THC.
Comparable studies
Other preclinical and animal studies on cannabis, most cited first.
Citations in the library
Cited by 3
- Tolerance to hypothermic and antinoceptive effects of ∆9-tetrahydrocannabinol (THC) vapor inhalation in rats. Pharmacology, Biochemistry, and Behavior September 2018
- Chronic administration during early adulthood does not alter the hormonally-dependent disruptive effects of delta-9-tetrahydrocannabinol (Δ9-THC) on complex behavior in female rats. Pharmacology, Biochemistry, and Behavior February 2014
- Long-term behavioral and pharmacodynamic effects of delta-9-tetrahydrocannabinol in female rats depend on ovarian hormone status. Addiction Biology January 2011
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