Effect of tabernanthine on the turnover time of brain catecholamines in normal and hypobaric hypoxic rats.
E Cretet, M Prioux-Guyonneau, C Jacquot, H Sentenac, J Wepierre
Naunyn-Schmiedeberg's Archives of Pharmacology August 1, 1980 DOI: 10.1007/bf00498566 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experiment Peer reviewed |
|---|---|
| Population | Normal and hypobaric hypoxic rats |
| Intervention | Tabernanthine |
| Topics | Ibogaine |
| Keywords | Brain Animals Rats Norepinephrine Catecholamines Dopamine Alkaloids Atmospheric pressure Kinetics Male Hypoxia |
| Key findings | Tabernanthine did not alter cerebral catecholamine levels but slightly decreased noradrenaline and dopamine turnover times at normal pressure. Hypobaric hypoxia lengthened turnover times, and tabernanthine antagonized this effect, completely at 5,200 m but only partially at 7,000 m, especially in dopaminergic areas. The authors suggest the effect may relate to the drug's stimulatory properties. |
Abstract
The central effects of tabernanthine on noradrenaline and dopamine turnover times were studied in the hypothalamus, the striatum and the remainder of the brain of normal and hypobaric hypoxic rats, the latter state corresponding to 5,200m (410mm Hg) and 7,000m (320mm Hg). Catecholamine cerebral level were not modified by the drug in either instance. At normal atmospheric pressure the catecholamine turnover times were slightly decreased by tabernanthine. Hypobaric hypoxia alone increased noradrenaline and dopamine turnover times by inhibiting oxygen-dependent enzymes. Tabernanthine antagonized the effect of hypobaric hypoxia especially in dopaminergic areas. Antagonism was complete at 5,200m but only partial at 7,000m. This phenomenon may be related to the stimulatory properties of the drug.
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| Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Rats | 1994 | Experimental study | |
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Citations in the library
Cited by 3
- Ibogaine modulates cocaine responses which are altered due to environmental habituation: in vivo microvoltammetric and behavioral studies. Pharmacology, Biochemistry, and Behavior November 1, 1994
- Benzodiazepine receptors are involved in tabernanthine-induced tremor: in vitro and in vivo evidence. European Journal of Pharmacology August 1, 1987
- Evidence for an activating effect of tabernanthine on rat brain catecholamine synthesis and elimination. Experientia December 1, 1984