Evidence for an activating effect of tabernanthine on rat brain catecholamine synthesis and elimination.
M Prioux-Guyonneau, E Mocaër-Cretet, Y Cohen, C Jacquot
Experientia December 1, 1984 DOI: 10.1007/bf01951904 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Population | Rats (inbred strains) |
| Intervention | Tabernanthine |
| Topics | Ibogaine |
| Keywords | Brain Hypothalamus Corpus striatum Animals Rats, inbred strains Norepinephrine Dopamine Dihydroxyphenylalanine Alkaloids Male |
| Key points | Tabernanthine increased the synthesis and elimination of catecholamines in the striatum and the rest of the brain, but not in the hypothalamus. The authors propose that the drug may activate catecholamine turnover in some brain structures by acting at two steps of the metabolic pathway, and discuss this in relation to a central stimulating action and a hypoxia-antagonistic effect. |
Abstract
Tabernanthine increased the synthesis and elimination of catecholamines (CA) in the striatum and the rest of the brain, but not in the hypothalamus. These data provide evidence that tabernanthine may activate CA turnover of some brain structures by acting at 2 steps of the metabolic pathway. The results are discussed in relation to a central stimulating action and a hypoxia antagonistic effect of this drug.