Comparison of effects of some 5-HT1 agonists on blood pressure and heart rate of normotensive anaesthetized rats.
H Dabiré, C Cherqui, B Fournier, H Schmitt
European Journal of Pharmacology August 21, 1987 DOI: 10.1016/0014-2999(87)90282-2 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Normotensive anaesthetized rats |
| Interventions | 8-OH-DPAT 5-MeODMT TFMPP ketanserin methysergide cocaine spiroxatrine |
| Topics | Serotonin |
| Citations | 47 |
| Key findings | The hypotension and bradycardia induced by 5-MeODMT and 8-OH-DPAT are due to stimulation of '5-HT1-like' receptors, probably the 5-HT1A subtype, while the 5-MeODMT-induced hypertension is ascribed to stimulation of 5-HT2 receptors. |
Abstract
The present experiments served to compare the effects of the 3 5-HT1 agonists, 8-OH-DPAT, 5-MeODMT and TFMPP on the blood pressure and heart rate of normotensive anaesthetized rats. All the agonists induced, after i.v. injection, a decrease in blood pressure and heart rate. The hypotensive effects of 5-MeODMT and TFMPP were preceded by an increase, suppressed by both ketanserin and methysergide. The decrease in blood pressure induced by 5-MeODMT and 8-OH-DPAT was not antagonized by ketanserin, cocaine (and methysergide for 8-OH-DPAT) but was antagonized by methysergide (for 5-MeODMT) and spiroxatrine (for both). Bradycardia was not susceptible to ketanserin and cocaine (for 5-MeODMT) or to ketanserin and methysergide (for 8-OH-DPAT) but to methysergide and spiroxatrine (for 5-MeODMT) and cocaine and spiroxatrine (for 8-OH-DPAT). These results suggested that the hypotension and bradycardia induced by 5-MeODMT and 8-OH-DPAT are due to the stimulation of '5-HT1-like' receptors and probably to the 5-HT1A subtype; the 5-MeODMT-induced hypertension being ascribed to the stimulation of 5-HT2 receptors.
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