Actions of certain amines on cerebral cortical neurones.
K Krnjevic, J W Phillis
British Journal of Pharmacology and Chemotherapy June 1, 1963 DOI: 10.1111/j.1476-5381.1963.tb01484.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Neurones in the cerebral cortex of cats |
| Interventions | imidazolylacetic acid dopamine ephedrine ergometrine catechol amines hydroxytryptamines gamma-aminobutyric acid atropine 5-hydroxytryptamine adrenaline dopa methylergometrine |
| Topics | LSD Serotonin |
| Keywords | Cerebral cortex Neurons Serous membrane Animals Cats Epinephrine Dopamine Tryptamines Gamma-aminobutyric acid Glutamic acid |
| Key findings | Many tryptamine and phenethylamine derivatives depressed cortical neuronal discharge evoked by synaptic activity or L-glutamate, with imidazolylacetic acid, dopamine, ephedrine, and ergometrine particularly effective. Catecholamines, hydroxytryptamines, and imidazolylacetic acid acted quickly and reversibly like gamma-aminobutyric acid, whereas ephedrine and lysergic acid diethylamide derivatives caused slower, more prolonged spike-amplitude depression resembling atropine. Some compounds, including 5-hydroxytryptamine, adrenaline, and ergometrine, also excited the same neurone at larger amounts, and dopa and methylergometrine were predominantly excitant. |
Abstract
A number of derivatives of tryptamine and phenethylamine, and certain other compounds, were tested on neurones in the cerebral cortex of cats by iontophoretic release from micro-pipettes. The characteristic action of many of these compounds was a depression of the neuronal discharge initiated by synaptic activity or by the application of L-glutamate; imidazolylacetic acid, dopamine, ephedrine and ergometrine were particularly effective. Catechol amines, hydroxytryptamines and imidazolylacetic acid had a relatively quick and rapidly reversible action, not unlike that of gamma-aminobutyric acid, whereas ephedrine and derivatives of lysergic acid diethylamide caused a slower and more prolonged depression of the amplitude of spikes, rather like atropine. Several compounds, including 5-hydroxytryptamine, adrenaline and ergometrine, could also excite the same neurone when larger amounts were applied. A few substances, such as dopa and methylergometrine, had a predominantly excitant action.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 6
- Antagonism of 5‐hydroxytryptamine by LSD 25 in the central nervous system: a possible neuronal basis for the actions of LSD 25 British Journal of Pharmacology October 1, 1970
- FURTHER STUDIES ON THE MODE OF ACTION OF PSYCHOTOMIMETIC DRUGS: ANTAGONISM OF THE EXCITATORY ACTIONS OF 5‐HYDROXYTRYPTAMINE BY METHYLATED DERIVATIVES OF TRYPTAMINE British Journal of Pharmacology March 1, 1974
- Effect of mescaline on single cortical neurones British Journal of Pharmacology December 1, 1971
- Serotonin Release from Brain Slices by Electrical Stimulation: Regional Differences and Effect of LSD Science September 22, 1967
- Neurophysiological support of consciousness during waking and sleep. Progress in Neurobiology December 1999
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