Inhibition of synaptosomal neurotransmitter uptake by hallucinogens.
M R Whipple, M G Reinecke, F H Gage
Journal of Neurochemistry April 1983 DOI: 10.1111/j.1471-4159.1983.tb08113.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Population | Hippocampal and caudate synaptosomes (rat or animal tissue not specified in the abstract) |
| Key points | Of 13 hallucinogens tested, all inhibited synaptosomal uptake of serotonin, norepinephrine, or dopamine except LSD and 2-bromolysergic acid diethylamide, which were inactive; indolealkylamines were generally more potent than phenylethylamines. The authors report that earlier findings of serotonin uptake inhibition by 5-methoxy-N,N-dimethyltryptamine and LSD in whole-brain synaptosomes could not be reproduced at concentrations 100 to 10,000 times higher than those originally stated. |
Abstract
The effect of 13 hallucinogens on the uptake of serotonin and norepinephrine into hippocampal synaptosomes and of serotonin and dopamine into caudate synaptosomes was found to be inhibitory, except for lysergic acid diethylamide and 2-bromolysergic acid diethylamide, which were inactive. The indolealkylamines were generally more potent than the phenylethylamines. The reported inhibition of uptake of serotonin by 5-methoxy-N,N-dimethyltryptamine and lysergic acid diethylamide into whole brain synaptosomes was not reproducible at concentrations 10(2) to 10(4) times higher than those stated in the literature.
Citations in the library
Cited by 10
- Differences Between the Mechanism of Action of MDMA, MBDB, and the Classic Hallucinogens. Identification of a New Therapeutic Class: Entactogens Journal of Psychoactive Drugs October 1, 1986
- Neuropharmacology of N,N-dimethyltryptamine Brain Research Bulletin April 30, 2016
- Stereochemical effects of 3,4-methylenedioxymethamphetamine (MDMA) and related amphetamine derivatives on inhibition of uptake of [3H]monoamines into synaptosomes from different regions of rat brain. Biochemical Pharmacology July 15, 1987
- N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function Frontiers in Neuroscience August 6, 2018
- Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter. Journal of Neural Transmission September 12, 2009
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