Connectivity pattern changes in default-mode network with deep non-REM and REM sleep.
Takahiko Koike, Shigeyuki Kan, Masaya Misaki, Satoru Miyauchi
Neuroscience Research April 2011 DOI: 10.1016/j.neures.2010.12.018 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational neuroimaging study Peer reviewed |
|---|---|
| Population | Participants undergoing fMRI and polysomnogram recording during REM, deep NREM, and light NREM sleep |
| Topics | Default mode network |
| Key findings | Functional connectivity among DMN core regions (posterior cingulate cortex, rostral anterior cingulate cortex, inferior parietal lobule) remained consistent across sleep states, whereas connectivity involving DMN subsystems in REM sleep differed from NREM sleep. The authors suggest the DMN core region and subsystems may not relate to arousal maintenance, but may respectively integrate brain regions and serve functions specific to each arousal level. |
Abstract
Recent studies have compared default-mode network (DMN) connectivity in different arousal levels to investigate the relationship between consciousness and DMN. The comparison between the DMN in rapid eye movement (REM) sleep with that in non-REM (NREM) sleep is useful for revealing the relationship between arousal level and DMN, because the arousal level is at its lowest during deep NREM, while during REM sleep it is as high as wakefulness. Functional magnetic resonance imaging (fMRI) and polysomnogram data were acquired from participants in REM, deep NREM, and light NREM sleep, and the DMN was compared using functional connectivity analysis. Our analysis revealed that functional connectivity among the DMN core regions - the posterior cingulate cortex, rostral anterior cingulate cortex, and inferior parietal lobule - remained consistent across sleep states. In contrast, connectivity involving the DMN subsystems of REM sleep differs from that of NREM sleep, and the change well accounts for the characteristics of REM sleep. Our results suggest that both the DMN core region and subsystems may not relate to the maintenance of arousal. The DMN core network and subsystems may respectively serve to integrate brain regions and perform function specific to each level of arousal.
Comparable studies
Other experimental studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Functional connectivity of default mode network components: Correlation, anticorrelation, and causality Healthy subjects | 2008 | Observational study using resting-state fMRI and seed correlation analysis | |
| Patterns of Brain Activity Supporting Autobiographical Memory, Prospection, and Theory of Mind, and Their Relationship to the Default Mode Network Healthy subjects | 2009 | Experimental study using fMRI | |
| Dynamic reconfiguration of the default mode network during narrative comprehension Human subjects | 2016 | Experimental study | |
| Broadband Cortical Desynchronization Underlies the Human Psychedelic State Healthy human participants | 2013 | Experimental study | |
| The brain on art: intense aesthetic experience activates the default mode network Human observers | 2012 | Observational study with fMRI and behavioral analysis |
Citations in the library
Cited by 22
- Dreaming as mind wandering: evidence from functional neuroimaging and first-person content reports. Frontiers in Human Neuroscience 2013
- Harmonic Brain Modes: A Unifying Framework for Linking Space and Time in Brain Dynamics The Neuroscientist September 1, 2017
- Sleep and dreaming are for important matters Frontiers in Psychology 2013
- A default mode of brain function in altered states of consciousness. February 26, 2013
- Neural correlates of consciousness during general anesthesia using functional magnetic resonance imaging (fMRI). February 26, 2013
and 17 more in the library
Cites 7
- Decoupling of the brain's default mode network during deep sleep Proceedings of the National Academy of Sciences June 19, 2009
- Intrinsic Brain Activity in Altered States of Consciousness Annals of the New York Academy of Sciences May 1, 2008
- Slow Wave Sleep Dreaming Sleep November 1, 1992
- Consciousness and Anesthesia Science November 7, 2008
- Persistent Default-Mode Network Connectivity During Light Sedation Human Brain Mapping January 24, 2008
and 2 more in the library