Single exposure to cocaine or ecstasy induces DNA damage in brain and other organs of mice.
Tathiana A. Alvarenga, Mônica L. Andersen, Daniel A Ribeiro, Paula Araujo, Camila Hirotsu, Jose L Costa, Murilo C Battisti, Sergio Tufik
Addiction Biology January 2010 DOI: 10.1111/j.1369-1600.2009.00179.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental animal study Peer reviewed |
|---|---|
| Population | Mice |
| Interventions | Cocaine MDMA |
| Duration | One hour after drug administration |
| Measures | Single cell gel (comet) assay |
| Topics | MDMA |
| Key findings | All doses of cocaine and MDMA tested induced DNA damage in mouse blood cells, and brain cells were affected at all doses administered. Extensive genotoxic damage in liver cells occurred only at the highest doses used. The authors conclude that cocaine and MDMA are potent genotoxins. |
Abstract
We evaluated the overall genetic damage induced by different doses of cocaine and MDMA (3,4-Methylenedioxymethamphetamine) in several organs. One hour after intraperitoneal drug administration, mice were euthanized; peripheral blood, liver and brain were collected, and the cellular suspensions were used for the single cell gel (comet) assay. We determined that all doses of cocaine and MDMA tested were able to induce DNA damage in blood cells. Extensive genotoxic damage was induced by cocaine or MDMA at the highest doses used in liver cells. Brain cells were affected by all doses administrated. These findings demonstrate that cocaine and MDMA are potent genotoxins.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 5
- Mechanisms of MDMA (Ecstasy)-Induced Oxidative Stress, Mitochondrial Dysfunction, and Organ Damage Current Pharmaceutical Biotechnology June 27, 2010
- Novel Psychoactive Phenethylamines: Impact on Genetic Material. International Journal of Molecular Sciences December 17, 2020
- Of mice and men on MDMA: a translational comparison of the neuropsychobiological effects of 3,4-methylenedioxymethamphetamine ('Ecstasy'). Brain Research November 14, 2019
- MDMA: interactions with other psychoactive drugs. Pharmacology, Biochemistry, and Behavior October 2011
- Increased oxidative-modifications of cytosolic proteins in 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-exposed rat liver. PROTEOMICS January 2011