The monoamine oxidase-B inhibitor L-deprenyl protects against 3,4-methylenedioxymethamphetamine-induced lipid peroxidation and long-term serotonergic deficits.

J Pharmacol Exp Ther May 1, 1995 DOI: 10.1016/s0022-3565(25)09490-x (opens in new tab)

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Characteristics	Peer reviewed
Topics	MDMA Serotonin

Abstract

The monoamine oxidase-B inhibitor L-deprenyl protects against 3,4-methylenedioxymethamphetamine-induced lipid peroxidation and long-term serotonergic deficits.

Inhibition of MAO-B protects against MDMA-induced neurotoxicity in the striatum. Psychopharmacology April 1995
Effect of acute monoamine depletion on 3,4-methylenedioxymethamphetamine-induced neurotoxicity. Pharmacol Biochem Behav July 1, 1993
5-HT2 antagonists stereoselectively prevent the neurotoxicity of 3,4-methylenedioxymethamphetamine by blocking the acute stimulation of dopamine synthesis: reversal by L-dopa. Journal of Pharmacology and Experimental Therapeutics 1990
L-Tyrosine Contributes to (+)-3,4-Methylenedioxymethamphetamine-Induced Serotonin Depletions The Journal of Neuroscience January 4, 2006
Selective 5-hydroxytryptamine2 receptor antagonists protect against the neurotoxicity of methylenedioxymethamphetamine in rats. Journal of Pharmacology and Experimental Therapeutics November 1, 1990

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Abstract

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