Bridging disparate symptoms of schizophrenia: a triple network dysfunction theory.
Tereza Nekovářová, Iveta Fajnerová, Jiří Horáček, Filip Španiel
Frontiers in Behavioral Neuroscience May 30, 2014 DOI: 10.3389/fnbeh.2014.00171 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | Default mode network |
| Keywords | Schizophrenia Theory of mind Self Forward model Salience network Central executive network |
| Key points | Proposes that dysfunctional switching between the default mode and central executive networks, related to aberrant salience network activity, may act as a unitary mechanism for diverse schizophrenia symptoms, including self-awareness deficits, theory of mind dysfunctions, and positive, negative, and cognitive domains. The authors cite prior studies and neuroimaging data as support. |
Abstract
Schizophrenia is a complex neuropsychiatric disorder with variable symptomatology, traditionally divided into positive and negative symptoms, and cognitive deficits. However, the etiology of this disorder has yet to be fully understood. Recent findings suggest that alteration of the basic sense of self-awareness may be an essential distortion of schizophrenia spectrum disorders. In addition, extensive research of social and mentalizing abilities has stressed the role of distortion of social skills in schizophrenia.This article aims to propose and support a concept of a triple brain network model of the dysfunctional switching between default mode and central executive network (CEN) related to the aberrant activity of the salience network. This model could represent a unitary mechanism of a wide array of symptom domains present in schizophrenia including the deficit of self (self-awareness and self-representation) and theory of mind (ToM) dysfunctions along with the traditional positive, negative and cognitive domains. We review previous studies which document the dysfunctions of self and ToM in schizophrenia together with neuroimaging data that support the triple brain network model as a common neuronal substrate of this dysfunction.
Comparable studies
Other theoretical and historical papers on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs | 2014 | Theoretical or philosophical paper | |
| The default mode network in cognition: a topographical perspective | 2021 | Theoretical or philosophical paper | |
| The default mode network: where the idiosyncratic self meets the shared social world | 2021 | Theoretical or philosophical paper | |
| The default-mode, ego-functions and free-energy: a neurobiological account of Freudian ideas | 2010 | Theoretical or philosophical paper | |
| Cooperation between the default mode network and the frontal–parietal network in the production of an internal train of thought | 2011 | Theoretical or philosophical paper |
Citations in the library
Cited by 19
- Triple Network Model Dynamically Revisited: Lower Salience Network State Switching in Pre-psychosis Frontiers in Physiology February 11, 2020
- Psilocybin disrupts sensory and higher order cognitive processing but not pre-attentive cognitive processing—study on P300 and mismatch negativity in healthy volunteers Psychopharmacology January 5, 2018
- Phenomenology and neurobiology of self disorder in schizophrenia: Secondary factors. Schizophrenia Research December 1, 2015
- Towards a Neurophenomenological Understanding of Self-Disorder in Schizophrenia Spectrum Disorders: A Systematic Review and Synthesis of Anatomical, Physiological, and Neurocognitive Findings Brain Sciences May 23, 2023
- Missing piece of the puzzle in the science of consciousness: Resting state and endogenous correlates of consciousness Consciousness and Cognition February 2, 2017
and 14 more in the library
Cites 7
- On the relationship between the “default mode network” and the “social brain” Frontiers in Human Neuroscience 2012
- Self-disturbance and schizophrenia: structure, specificity, pathogenesis (Current issues, New directions). Schizophrenia Research 2014
- The Neurodynamic Organization of Modality-Dependent Hallucinations Cerebral Cortex April 24, 2012
- What are the neurocognitive correlates of basic self-disturbance in schizophrenia?: Integrating phenomenology and neurocognition. Part 1 (Source monitoring deficits). Schizophrenia Research January 2014
- Subjective symptoms of schizophrenia in research and the clinic: the basic symptom concept. Schizophrenia Bulletin January 2009
and 2 more in the library