Twenty percent better with 20 micrograms? A qualitative study of psychedelic microdosing self-rapports and discussions on YouTube
Martin Andersson, Anette Kjellgren
Harm Reduction Journal November 28, 2019 DOI: 10.1186/s12954-019-0333-3 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Qualitative study Peer reviewed |
|---|---|
| Population | YouTube videos and comments about psychedelic microdosing |
| Intervention | Psychedelic microdosing |
| Topics | Microdosing |
| Keywords | Thematic analysis Comprehension Pharmacology Applied psychology |
| Citations | 35 |
| Key findings | Microdosing of psychedelic substances, primarily LSD and psilocybin, was used for therapeutic and enhancement purposes, with predominantly beneficial effects reported, and therapeutic effects for depression appeared especially noteworthy. |
Abstract
Abstract Background Psychedelic microdosing is the trending practice of using tiny repeated doses of psychedelic substances to facilitate a range of supposed benefits. With only a few published studies to date, the subject is still under-researched, and more knowledge is warranted. Social media and internet discussion forums have played a vital role in the growing visibility of the microdosing phenomenon, and the present study utilized YouTube contents to improve comprehension of the microdosing practice as well as the social interactions and discussions around microdosing.
Methods: Microdosing self-disclosure in YouTube videos and their following comments were qualitatively analyzed by inductive thematic analysis. Various software was utilized to enable gathering and sorting relevant data.
Results: Microdosing of psychedelic substances, primarily LSD and psilocybin, was used for therapeutic and enhancement purposes, and predominantly beneficial effects were reported. Many different applications and outcomes were discussed, and therapeutic effects for depression appeared especially noteworthy. Intentions for use were recognized as an influencing factor for the progression and outcomes of microdosing. The function of social interactions was mainly to discuss views on the microdosing phenomenon, strategies for optimal results, minimize risks, and share emotional support.
Conclusions: Potentially, microdosing could provide some of the same benefits (for certain conditions) as full-dose interventions with less risk of adverse reactions related to the sometimes intense experiences of higher doses. Microdosing may well also mean additional benefits, as well as risks, through the repeated exposure over extended periods.
Comparable studies
Other qualitative studies on microdosing, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psychedelic microdosing benefits and challenges: an empirical codebook Active microdosing community | 2019 | Mixed-methods study | |
| Narrative identity, rationality, and microdosing classic psychedelics People who had microdosed classic psychedelics | 2019 | Qualitative study | n = 30 |
| Accounting for Microdosing Classic Psychedelics People who had microdosed classic psychedelics | 2019 | Qualitative study | n = 30 |
| Experiences of microdosing psychedelics in an attempt to support wellbeing and mental health. People who microdose psychedelic drugs | 2023 | Qualitative study | n = 13 |
| Qualitative content analysis of expectations in participants with depression about to begin LSD microdosing treatment: Identifying the need for psychedelic expectancy measures. Individuals with major depressive disorder (MDD) | 2025 | Qualitative study | n = 23 |
Citations in the library
Cited by 29
- The emerging science of microdosing: A systematic review of research on low dose psychedelics (1955–2021) and recommendations for the field Neuroscience & Biobehavioral Reviews May 21, 2022
- Acute Mood-Elevating Properties of Microdosed Lysergic Acid Diethylamide in Healthy Volunteers: A Home-Administered Randomized Controlled Trial. Biological Psychiatry September 15, 2023
- Potential safety, benefits, and influence of the placebo effect in microdosing psychedelic drugs: A systematic review Neuroscience & Biobehavioral Reviews October 5, 2020
- Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats. Molecular Psychiatry September 1, 2023
- MDLSD: study protocol for a randomised, double-masked, placebo-controlled trial of repeated microdoses of LSD in healthy volunteers Trials April 23, 2021
and 24 more in the library
Cites 24
- Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study. The Lancet Psychiatry May 17, 2016
- Psychedelics as Medicines: An Emerging New Paradigm Clinical Pharmacology & Therapeutics November 4, 2016
- Psychiatry & the psychedelic drugs. Past, present & future. Neuropharmacology December 25, 2017
- Antidepressive, anxiolytic, and antiaddictive effects of ayahuasca, psilocybin and lysergic acid diethylamide (LSD): a systematic review of clinical trials published in the last 25 years Therapeutic Advances in Psychopharmacology March 18, 2016
- Potential Therapeutic Effects of Psilocybin. Neurotherapeutics July 1, 2017
and 19 more in the library