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Research on the construction of an adaptive mindfulness-based cognitive therapy system based on large language models and its efficacy in addressing college students’ anxiety

Yunlong Jia

Frontiers in Psychology October 16, 2026 DOI: 10.3389/fpsyg.2026.1800278 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Randomized controlled trial Peer reviewed
Sample size 120
Population College students with anxiety disorders
Measures Self-Rating Anxiety Scale (SAS), Mindful Attention Awareness Scale (MAAS), Automatic Thoughts Questionnaire (ATQ)
Topics Anxiety Meditation
Key findings An adaptive MBCT system using large language models was associated with lower anxiety (SAS 38.26 vs 45.89), higher mindfulness (MAAS 68.73 vs 56.41), and lower automatic-thought scores (ATQ 42.15) compared with a control group among 120 college students with anxiety. The authors conclude the system may be effective in reducing anxiety symptoms, improving mindfulness, and enhancing cognitive processes.

Abstract

To handle the problem of resource scarcity and lack of personalization and adaptability in the traditional approach to mindfulness-based cognitive therapy (MBCT) in dealing with college students with anxiety disorders, this study proposes the use of the natural language interface and adaptability properties of large language models (LLMs) to come up with an intelligent college-level MBCT intervention system. To begin with, the system functional requirements and the logic of the system intervention were explained in line with the fundamental ideas of MBCT and the cognitive features of students with anxiety. Second, it was created through a four-stage adaptive architecture that includes perception analysis, intervention, and feedback, providing a dynamic process for user status identification, personal generation of intervention plans, and real-time optimization of the intervention process. Finally, there was a randomized controlled trial whose subjects were 120 college students with anxiety who were separated into an experimental group and a control group. The effectiveness of the intervention was assessed using tools such as the Self-Rating Anxiety Scale (SAS), the Mindful Attention Awareness Scale (MAAS), and the Automatic Thoughts Questionnaire (ATQ). The findings indicated that the SAS score of the experimental group (38.26 ± 5.12) was significantly less than that of the control group (45.89 ± 6.34), the MAAS score (68.73 ± 7.25) was significantly higher than that of the control group (56.41 ± 8.13); and the ATQ score (42.15 ± 6.08) was significantly less than that of the control group. The study reveals that an adaptive MBCT system using large language models may be effective in reducing anxiety symptoms among college students, improving mindfulness, and enhancing cognitive processes, offering a new, readily available strategy for addressing anxiety in college students.

Comparable studies

Other randomized controlled trials on anxiety, most cited first.

Study Year Design Participants
Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients 2000 Randomized controlled trial n = 145
Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial Cancer patients with life-threatening diagnoses and symptoms of depression and/or anxiety 2016 Randomized controlled trial n = 51
Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial Patients with cancer-related anxiety and depression 2016 Double-blind, placebo-controlled, crossover trial n = 29
Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance Hallucinogen-naïve adults reporting regular participation in religious or spiritual... 2006 Double-blind study n = 36
Pilot Study of Psilocybin Treatment for Anxiety in Patients With Advanced-Stage Cancer Adults with advanced-stage cancer and anxiety 2010 Double-blind, placebo-controlled study n = 12

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