Efficacy of antipsychotics to reverse phencyclidine-induced social interaction deficits in female rats--a preliminary investigation.
Shikha Snigdha, Joanna C. Neill
Behavioural Brain Research March 5, 2008 DOI: 10.1016/j.bbr.2007.10.012 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experimental study Peer reviewed |
|---|---|
| Population | Female rats |
| Interventions | Phencyclidine (PCP) haloperidol clozapine ziprasidone |
| Key findings | The study set out to test whether sub-chronic PCP treatment causes social interaction deficits in female rats and whether haloperidol, clozapine, or ziprasidone reverse them. The abstract notes that negative symptoms such as social behaviour deficits have rarely been modelled in female rats. No results are reported in the abstract. |
Abstract
Sub-chronic phencyclidine (PCP) treatment mimics certain aspects of schizophrenia symptomology in rats. However, there is a marked lack of attempts to model negative symptomology such as social behaviour deficits in female rats. This study was conducted to assess whether sub-chronic PCP treatment produces social interaction deficits in female rats and to ascertain if these deficits can be reversed by either typical (haloperidol) or atypical (clozapine and ziprasidone) antipsychotics.
Citations in the library
Cited by 11
- Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Progress in Neuro-Psychopharmacology and Biological Psychiatry January 10, 2012
- The antipsychotic potential of Salix Mucronata on ketamine-induced rats. IBRO Neuroscience Reports December 1, 2024
- Multidimensional analysis of social withdrawal in the sub-chronic phencyclidine rat model for schizophrenia. Psychopharmacology April 23, 2026
- Neurosteroid pregnenolone sulfate, alone, and as augmentation of lurasidone or tandospirone, rescues phencyclidine-induced deficits in cognitive function and social interaction. Behavioural Brain Research September 17, 2018
- Male rats treated with subchronic PCP show intact olfaction and enhanced interest for a social odour in the olfactory habituation/dishabituation test Behavioural Brain Research June 1, 2018
and 6 more in the library
Cites 4
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- The effect of atypical and classical antipsychotics on sub-chronic PCP-induced cognitive deficits in a reversal-learning paradigm. Behavioural Brain Research May 15, 2006
- Phencyclidine in the social interaction test: an animal model of schizophrenia with face and predictive validity. Reviews in the Neurosciences 1999