18-Methoxycoronaridine blocks acquisition but enhances reinstatement of a cocaine place preference.
Sarah E McCallum, Stanley D Glick
Neuroscience Letters April 11, 2009 DOI: 10.1016/j.neulet.2009.04.019 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Male Sprague-Dawley rats |
| Interventions | 18-methoxycoronaridine (18-MC) Cocaine |
| Topics | Ibogaine |
| Keywords | Animals Rats, sprague-dawley Cocaine Dopamine uptake inhibitors Self administration Analysis of variance Behavior, animal Behavior, addictive Conditioning, operant Time factors Male Extinction, psychological Reinforcement, psychology |
| Key findings | 18-MC attenuated acquisition of a cocaine conditioned place preference but did not affect its expression and enhanced reinstatement after extinction. The authors argue that acquisition, expression, and reinstatement of a CPP likely involve separate mechanisms. |
Abstract
The iboga alkaloid congener, 18-methoxycoronaridine (18-MC), decreases self-administration of multiple drugs of abuse. Here, in a biased procedure, we investigated whether 18-MC would have a similar effect on the acquisition, expression and reinstatement of a cocaine conditioned place preference (CPP) in male Sprague-Dawley rats. While 18-MC attenuated acquisition of a cocaine CPP, it had no effect on CPP expression, and enhanced the reinstatement of cocaine CPP following extinction. Our results are consistent with those obtained using ibogaine, but reinforce the notion that acquisition, expression and reinstatement of a CPP likely involve separate mechanisms.
Comparable studies
Other preclinical and animal studies on ibogaine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Noncompetitive Functional Inhibition at Diverse, Human Nicotinic Acetylcholine Receptor Subtypes by Bupropion, Phencyclidine, and Ibogaine TE671/RD cells (human muscle-type nAChR) and SH-SY5Y neuroblastoma cells (human... | 1999 | In vitro study | |
| Degeneration of Purkinje cells in parasagittal zones of the cerebellar vermis after treatment with ibogaine or harmaline. Ibogaine- or harmaline-treated rats | 1993 | Experimental animal study | |
| Effects and aftereffects of ibogaine on morphine self-administration in rats. Rats | 1991 | Preclinical experimental study | |
| Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Rats | 1994 | Experimental study | |
| Glial Cell Line-Derived Neurotrophic Factor Mediates the Desirable Actions of the Anti-Addiction Drug Ibogaine against Alcohol Consumption Rats | 2005 | Experimental study |
Citations in the library
Cites 6
- 18-Methoxycoronaridine, a non-toxic iboga alkaloid congener: effects on morphine and cocaine self-administration and on mesolimbic dopamine release in rats. Brain Research May 6, 1996
- Ibogaine fails to interrupt the expression of a previously established one-trial morphine place preference. Progress in Neuro-Psychopharmacology and Biological Psychiatry July 1, 1996
- Ibogaine interferes with the establishment of amphetamine place preference learning. Experimental and Clinical Psychopharmacology May 1, 1997
- Brain regions mediating alpha3beta4 nicotinic antagonist effects of 18-MC on methamphetamine and sucrose self-administration. European Journal of Pharmacology October 1, 2008
- 18-Methoxycoronaridine acts in the medial habenula and/or interpeduncular nucleus to decrease morphine self-administration in rats. European Journal of Pharmacology March 24, 2006
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