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Ibogaine interferes with the establishment of amphetamine place preference learning.

I Moroz, Linda A. Parker, S Siegel

Experimental and Clinical Psychopharmacology May 1, 1997 DOI: 10.1037//1064-1297.5.2.119 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Experimental study Peer reviewed
Population Rats
Intervention Ibogaine
Topics Ibogaine
Citations 11
Key findings Ibogaine blocked amphetamine-induced place preference after one or two conditioning trials but was less effective after four trials, likely due to tolerance to ibogaine.

Abstract

The ability of ibogaine, injected 24 hr before amphetamine, to modify the establishment of amphetamine-induced place preference learning was assessed. A single injection of ibogaine blocked the establishment of amphetamine place preference after 1 or 2 conditioning trials, but it was less effective after 4 trials. The reduced effectiveness of ibogaine across multiple conditioning trials appears to be the result of the development of tolerance to ibogaine.

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