Selective natural kappa opioid and cannabinoid receptor agonists with a potential role in the treatment of gastrointestinal dysfunction
Jakub Fichna, Rudolf Schicho, Anna Janecka, Jordan Kordian Zjawiony, Martin Storr
Drug News & Perspectives 2009 DOI: 10.1358/dnp.2009.22.7.1400219 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Citations | 19 |
| Key findings | The review consolidates knowledge on salvinorin A and related neoclerodane diterpenoids from Salvia divinorum, emphasizing their effects on gastrointestinal tissues. The authors propose that structural changes to salvinorin A may facilitate future therapeutic use of its derivatives in human disease. |
Abstract
Salvinorin A is the major active ingredient of Salvia divinorum, a plant used by the Mazatec Indians of Mexico for spiritual and medical purposes. Different preparations from S. divinorum are also used in traditional healing practices to treat gastrointestinal disorders, including diarrhea. The recent extensive research on salvinorin A and other neoclerodane diterpenoids derived from S. divinorum resulted in a large number of reports describing their isolation, synthesis and structure-activity relationship. This review summarizes the present knowledge on salvinorin A and its analogues, with a focus on the effects on gastrointestinal tissues. We furthermore discuss structural changes in salvinorin A that may facilitate future use of its derivatives in human disease.
Citations in the library
Cited by 7
- Neuropharmacology of the naturally occurring kappa-opioid hallucinogen salvinorin A. Pharmacological Reviews June 1, 2011
- From local to global-fifty years of research on Salvia divinorum. Journal of Ethnopharmacology February 3, 2014
- Pharmacological activity of salvinorin A, the major component of Salvia divinorum. Pharmacological Reports 2011
- A unique natural selective kappa-opioid receptor agonist, salvinorin A, and its roles in human therapeutics. Phytochemistry May 1, 2017
- A Report of Nausea and Vomiting with Discontinuation of Chronic Use of Salvia divinorum Case Reports in Medicine August 22, 2015
and 2 more in the library
Cites 37
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and 32 more in the library