A defined network of fast-spiking interneurons in orbitofrontal cortex: responses to behavioral contingencies and ketamine administration.
Michael C. Quirk, Dara L Sosulski, Claudia E Feierstein, Naoshige Uchida, Zachary F Mainen
Frontiers in Systems Neuroscience 2009 DOI: 10.3389/neuro.06.013.2009 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Electrophysiological study in rats Peer reviewed |
|---|---|
| Population | Rats performing a goal-directed behavioral task |
| Intervention | Ketamine |
| Topics | Depression Esketamine Ketamine |
| Keywords | Fast-spiking interneuron Motivation Parvalbumin Psychosis Schizophrenia |
| Key points | Putative fast-spiking interneurons in rat orbitofrontal cortex showed temporally correlated firing during a goal-directed task and their activity co-varied with behavioral response latency, an indicator of motivational state. Systemic ketamine preferentially inhibited this cell class. The authors argue these results support the idea that orbitofrontal fast-spiking interneurons are a critical link in the regulation of motivation by prefrontal circuits in normal and abnormal states. |
Abstract
Orbitofrontal cortex (OFC) is a region of prefrontal cortex implicated in the motivational control of behavior and in related abnormalities seen in psychosis and depression. It has been hypothesized that a critical mechanism in these disorders is the dysfunction of GABAergic interneurons that normally regulate prefrontal information processing. Here, we studied a subclass of interneurons isolated in rat OFC using extracellular waveform and spike train analysis. During performance of a goal-directed behavioral task, the firing of this class of putative fast-spiking (FS) interneurons showed robust temporal correlations indicative of a functionally coherent network. FS cell activity also co-varied with behavioral response latency, a key indicator of motivational state. Systemic administration of ketamine, a drug that can mimic psychosis, preferentially inhibited this cell class. Together, these results support the idea that OFC-FS interneurons form a critical link in the regulation of motivation by prefrontal circuits during normal and abnormal brain and behavioral states.
Comparable studies
Other preclinical and animal studies on ketamine for depression, most cited first.
Citations in the library
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- A Comprehensive Review of the Current Status of the Cellular Neurobiology of Psychedelics Biology October 28, 2023
- Mania following ketamine abuse. Neuropsychiatric Disease and Treatment 2016
and 7 more in the library
Cites 3
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- Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex Journal of Neuroscience April 15, 1997
- Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors. Biological Psychiatry February 15, 2008