Mania following ketamine abuse.
Yuan-Yuan Lu, Chieh-Hsin Lin, Hsien-Yuan Lane
Neuropsychiatric Disease and Treatment 2016 DOI: 10.2147/ndt.s97696 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | 26-year-old man who abused ketamine by inhalation |
| Duration | 12 months of abuse |
| Topics | Ketamine Esketamine |
| Keywords | Antidepressant Bipolar Mania |
| Citations | 17 |
| Key findings | A possible relationship between manic symptoms and ketamine abuse is suggested by this case. |
Abstract
Ketamine, a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, has multiple clinical uses. On the other hand, ketamine abuse or recreational use has been gaining increasing attention. Induction of mania and psychotic symptoms has been reported in a patient receiving IV ketamine therapy for reflex sympathetic dystrophy. We here report a 26 year-old man who abused ketamine by inhalation for 12 months and developed manic-like symptoms after ketamine use. This case suggests a possible relationship between manic symptoms and ketamine abuse. To the best of our knowledge, this may be the first report regarding mania after recreational use of ketamine.