Influence of dietary fats on Ecstasy-induced hyperthermia.
E M Mills, K L Weaver, E Abramson, M Pfeiffer, J E Sprague
British Journal of Pharmacology May 29, 2007 DOI: 10.1038/sj.bjp.0707312 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Controlled experimental animal study Peer reviewed |
|---|---|
| Population | Male Sprague-Dawley rats |
| Interventions | High-fat diet MDMA |
| Dose | MDMA 10 mg kg(-1), s.c.; high-fat diet 60% kcal; lower-fat diet 10% kcal |
| Duration | 28 days of diet before MDMA challenge; plasma free fatty acids measured 30 and 60 minutes after MDMA |
| Topics | MDMA |
| Keywords | Muscle, skeletal Mitochondria, muscle Animals Rats, sprague-dawley Fever N-methyl-3,4-methylenedioxyamphetamine Thyroxine Dietary fats Fatty acids, nonesterified Ion channels Mitochondrial proteins Uncoupling agents Body temperature Blotting, western Diet, fat-restricted Injections, subcutaneous Analysis of variance Thermogenesis Time factors Male Adipose tissue, brown Uncoupling protein 1 Uncoupling protein 3 |
| Key findings | A high-fat diet (60% kcal) for 28 days did not change body weight, plasma thyroxine, or UCP1/UCP3 protein expression in rats, but it raised circulating free fatty acids and increased MDMA-induced thermogenesis compared with a 10% kcal lower-fat diet. After MDMA, free fatty acids decreased in high-fat-fed rats but were markedly elevated in lower-fat-fed rats. The authors conclude that high-fat feeding regulates MDMA-induced thermogenesis by augmenting UCP activation rather than its expression. |
Abstract
Background and
Purpose: Studies were designed to examine the effects of dietary fats on metabolic effects of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy). These effects included hyperthermia, expression of uncoupling protein (UCP1 and 3) in brown adipose tissue or skeletal muscle and plasma free fatty acid (FFA) levels. Experimental approach: Male Sprague-Dawley rats were fed either a high-fat diet (HFD, 60% kcal) or a lower fat isocaloric controlled diet (LFD, 10% kcal) for 28 days before MDMA challenge. Key
Results: No significant differences were observed between LFD and HFD groups in terms of body weight, plasma thyroxine (T4) levels and expression of brown fat UCP1 or skeletal muscle UCP3 protein. HFD significantly raised levels of circulating FFA and potentiated the thermogenesis induced by MDMA (10 mg kg(-1), s.c.), compared to the effects of the LFD. Moreover, 30 and 60 min after MDMA administration, plasma FFA levels decreased in HFD animals, but were markedly elevated in the LFD group. Conclusions and
Implications: These results indicate that high-fat feeding regulates MDMA-induced thermogenesis by augmenting the activation of UCP rather than its expression.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 9
- Effects of repeated treatment with MDMA on working memory and behavioural flexibility in mice Addiction Biology January 19, 2012
- The influence of the host microbiome on 3,4-methylenedioxymethamphetamine (MDMA)-induced hyperthermia and vice versa Scientific Reports March 13, 2019
- Bile acids and the gut microbiome are involved in the hyperthermia mediated by 3,4-methylenedioxymethamphetamine (MDMA). Scientific Reports June 24, 2024
- Influence of adrenalectomy on the gut microbiome and MDMA-induced hyperthermia. European Journal of Pharmacology April 15, 2023
- Reversal of temperature responses to methylone mediated through bi-directional fecal microbiota transplantation between hyperthermic tolerant and naïve rats. Temperature 2022
and 4 more in the library
Cites 3
- Cutaneous Vasoconstriction Contributes to Hyperthermia Induced by 3,4-Methylenedioxymethamphetamine (Ecstasy) in Conscious Rabbits Journal of Neuroscience November 1, 2001
- Carvedilol reverses hyperthermia and attenuates rhabdomyolysis induced by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) in an animal model* Critical Care Medicine June 1, 2005
- Effects of (+/-)3,4-methylenedioxymethamphetamine, (+/-)3,4-methylenedioxyamphetamine and methamphetamine on temperature and activity in rhesus macaques. Neuroscience October 13, 2006