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Ketamine bladder syndrome: an important differential diagnosis when assessing a patient with persistent lower urinary tract symptoms.

Shalom Srirangam, Joe Mercer

BMJ Case Reports September 30, 2012 DOI: 10.1136/bcr-2012-006447 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Case study Case report Peer reviewed
Sample size 1
Population A young male recreational ketamine user with lower urinary tract symptoms
Intervention Ketamine
Duration 5-year history of ketamine consumption; 2-year history of lower urinary tract symptoms
Topics Ketamine Esketamine
Keywords Humans Substance-related disorders Diagnosis, differential Adult Male Nocturia
Key findings The authors argue that recreational ketamine use can cause serious, frequently irreversible urinary tract damage, illustrated by a young man with a five-year history of ketamine consumption and two years of lower urinary tract symptoms. They contend that management is largely limited to analgesia and that stopping ketamine before irreversible damage occurs is the best way to avoid radical reconstructive surgery in end-stage disease.

Abstract

The recreational use of ketamine is increasing in popularity due to its dissociative and paralytic effects, ease of availability and low cost. However, serious and frequently irreversible damage to the urinary tract is a recently recognised side effect of recreational ketamine use. The authors present a case of a young male patient with a 2-year history of troublesome lower urinary tract symptoms and a 5-year history of ketamine consumption. Medical management of such patients is largely limited to analgesia alone, and cessation of ketamine use before irreversible damage occurs remains the best means of avoiding the radical reconstructive surgery required in end-stage disease. This case and an accompanying review of the available literature illustrate the importance of early recognition of ketamine bladder syndrome in recreational users.

Comparable studies

Other case reports and case series on ketamine, most cited first.

Study Year Design Participants
The destruction of the lower urinary tract by ketamine abuse: a new syndrome? Young recreational abusers of street-ketamine in Hong Kong referred to urology units 2008 Retrospective case series n = 59
Electroconvulsive Therapy, Ketamine, and Esketamine in a Patient with Major Depressive Disorder and Multiple Comorbidities: A Case Report over 10-year Treatment from Adolescence to Adulthood. A patient with treatment-resistant depression and comorbid generalized anxiety... 2025 Case report n = 1
Treatment of compulsive behaviour in eating disorders with intermittent ketamine infusions Chronic and treatment-resistant eating disorder patients 1998 Case series n = 15
Oral Administration of the NMDA Receptor Antagonist S-Ketamine as Add-On Therapy of Depression: A Case Series Four depressed patients taking standard antidepressants 2009 Case series n = 4
A longitudinal case series of IM ketamine for patients with severe and enduring eating disorders and comorbid treatment‐resistant depression Patients with enduring eating disorders and treatment-resistant depression 2021 Case series n = 4

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