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Cystitis due to the use of ketamine as a recreational drug: a case report.

Britt Colebunders, Peter Van Erps

Journal of Medical Case Reports June 26, 2008 DOI: 10.1186/1752-1947-2-219 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Case study Case report Peer reviewed
Sample size 1
Population A 20-year-old man with a 7-month history of urinary symptoms following weekly recreational ketamine use
Intervention Ketamine
Duration 7-month history of symptoms; weekly ketamine use
Topics Esketamine Ketamine
Key findings A 20-year-old man developed urinary frequency, nocturia, urgency, suprapubic discomfort during micturition, and severe haematuria after beginning weekly recreational ketamine use. Ultrasound showed a thickened bladder wall and cystoscopy showed mild inflammatory changes, while other tests were negative. The authors note only nine prior cases of ketamine-associated ulcerative cystitis and expect more cases in young adults as recreational ketamine use increases.

Abstract

Introduction: Ketamine is a derivative of phencyclidine and is a dissociative anaesthetic. Its use as a recreational drug is on the increase among young adults attending clubs and parties. Case presentation: We describe the case of a 20-year-old man who presented with a 7-month history of urinary frequency, nocturia, urgency, suprapubic discomfort during micturition and episodes of severe haematuria shortly after commencing weekly recreational ketamine use. Complementary examinations were negative except for a thickened bladder wall on ultrasound examination and mild inflammatory changes on cystoscopy. So far only nine cases of ketamine-associated ulcerative cystitis have been described.

Conclusion: We expect that in the future an increasing number of cases of cystitis caused by ketamine use will be seen in young adults.

Comparable studies

Other case reports and case series on ketamine, most cited first.

Study Year Design Participants
The destruction of the lower urinary tract by ketamine abuse: a new syndrome? Young recreational abusers of street-ketamine in Hong Kong referred to urology units 2008 Retrospective case series n = 59
Electroconvulsive Therapy, Ketamine, and Esketamine in a Patient with Major Depressive Disorder and Multiple Comorbidities: A Case Report over 10-year Treatment from Adolescence to Adulthood. A patient with treatment-resistant depression and comorbid generalized anxiety... 2025 Case report n = 1
Treatment of compulsive behaviour in eating disorders with intermittent ketamine infusions Chronic and treatment-resistant eating disorder patients 1998 Case series n = 15
Oral Administration of the NMDA Receptor Antagonist S-Ketamine as Add-On Therapy of Depression: A Case Series Four depressed patients taking standard antidepressants 2009 Case series n = 4
A longitudinal case series of IM ketamine for patients with severe and enduring eating disorders and comorbid treatment‐resistant depression Patients with enduring eating disorders and treatment-resistant depression 2021 Case series n = 4

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