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Combining emotion regulation and mindfulness skills for preventing depression relapse: a randomized-controlled study

Matilde Elices, Joaquim Soler, Albert Feliu-Soler, Cristina Carmona, T. Tiana, Juan C Pascual, A. García-Palacios, E. Álvarez

Borderline Personality Disorder and Emotion Dysregulation July 5, 2017 DOI: 10.1186/s40479-017-0064-6 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Randomized controlled trial Peer reviewed
Sample size 75
Population Adults with major depressive disorder in complete or partial remission (79% female; mean age 52 years)
Intervention psychoeducative program
Duration 10-week treatment period, 1-year follow-up
Topics Depression Meditation
Key findings The combined emotion regulation and mindfulness skills training was not more effective than psychoeducation in preventing depression relapse over one year. Both per-protocol and intention-to-treat analyses showed significant reductions in depressive symptoms and overall psychopathology in the combined training group, but neither intervention increased dispositional mindfulness.

Abstract

BackgroundDialectical behavioral therapy (DBT) skills have become increasingly used to treat several psychiatric conditions, including major depressive disorder (MDD). The aim of the study was to investigate the efficacy of an intervention that combines emotion regulation and mindfulness skills of DBT to prevent depression relapse/recurrence.MethodsA total of 75 individuals (79% females; mean age, 52 years) with a diagnosis of MDD in complete or partial remission were recruited. Participants were randomly allocated either to an intervention combining emotion regulation and mindfulness skills (ER + M group, n = 37) or to a psychoeducative program (n = 38). After the 10-week treatment period, participants were followed for 1 year. Analyses were run in per-protocol (PP) and intention-to-treat (ITT) samples. The primary outcome measure was time to depression relapse/recurrence.ResultsER + M training was not more effective than the control intervention in preventing depression relapse. However, PP and ITT analyses showed that participants trained in ER + M presented a significant reduction in depressive symptoms and overall psychopathology. Based on the PP and ITT analyses, neither of the interventions were related with an increase in dispositional mindfulness.ConclusionsMore studies are needed to confirm the efficacy of ER + M to decrease depressive symptoms and overall psychopathology.Trial registrationNCT02747134. Registered on 20 April 2016.

Comparable studies

Other randomized controlled trials on depression, most cited first.

Study Year Design Participants
A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression Subjects with DSM-IV major depression (treatment resistant) 2006 Randomized, placebo-controlled, double-blind crossover study n = 18
Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients 2000 Randomized controlled trial n = 145
Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial Cancer patients with life-threatening diagnoses and symptoms of depression and/or anxiety 2016 Randomized controlled trial n = 51
Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial Patients with cancer-related anxiety and depression 2016 Double-blind, placebo-controlled, crossover trial n = 29
Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Recovered recurrently depressed patients 2004 Randomized controlled trial n = 73

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