Occipital long-interval paired pulse TMS leads to slow wave components in NREM sleep.
Mihkel Stamm, Jaan Aru, Renate Rutiku, Talis Bachmann
Consciousness and Cognition September 2015 DOI: 10.1016/j.concog.2015.04.024 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental within-subject EEG study Peer reviewed |
|---|---|
| Interventions | Transcranial magnetic stimulation (TMS) paired-pulse TMS |
| Measures | EEG |
| Keywords | Consciousness EEG Lici Paired-pulse tms Plasticity Sleep Slow waves |
| Key findings | Paired-pulse occipital TMS at a 100 ms interval during NREM sleep evoked a robust positive EEG deflection starting around 200 ms after the second pulse, which was absent during wakefulness and after single pulses in sleep. The authors suggest this long-interval paired-pulse paradigm may manipulate visual cortex plasticity and help evaluate states of consciousness. |
Abstract
Neural correlates of conscious vs unconscious states can be studied by contrasting EEG markers of brain activity between those two states. Here, a task-free experimental setup was used to study the state dependent effects of occipital transcranial magnetic stimulation (TMS). EEG responses to single and paired pulse TMS with an inter-stimulus-interval (ISI) of 100 ms were investigated under Non-REM (NREM) sleep and wakefulness. In the paired pulse TMS condition adopting this long ISI, a robust positive deflection starting around 200 ms after the second pulse was found. This component was not obtained under wakefulness or when a single TMS pulse was applied in sleep. These findings are discussed in the context of NREM sleep slow waves. The present results indicate that the long interval paired-pulse paradigm could be used to manipulate plasticity processes in the visual cortex. The present setup might also become useful for evaluating states of consciousness.
Citations in the library
Cited by 2
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