Mechanisms Contributing to Cognitive Deficits in Cannabis Users
Romina Mizrahi, Jeremy J. Watts, Kuei Yuan Tseng
Neuropharmacology April 14, 2017 DOI: 10.1016/j.neuropharm.2017.04.018 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Cannabis |
| Key findings | Argues that sustained CB1 receptor activation, based largely on preclinical animal models, is a major contributing factor to cognitive deficits associated with chronic cannabis use, especially in working memory and decision-making, while noting that few studies have directly assessed CB1 receptors' role in human brain function. |
Abstract
Studies from preclinical animal models indicate that sustained activation of CB1 receptor signaling is a major contributing factor for the onset of cognitive deficits associated to chronic cannabis use, in particular within the working memory and decision-making domains. Yet, very few studies have been designed to directly assess the role of CB1 receptors in mediating the effects of cannabis on human brain function. This perspective review article provides an overview of current state of knowledge on possible neurobiological mechanisms accounting for the detrimental effects of chronic cannabis use on cognition and related changes in brain structure and functional connectivity.
Comparable studies
Other narrative reviews on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Causal association between cannabis and psychosis: examination of the evidence | 2004 | Review | |
| Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history. General (historical and pharmacological review) | 2018 | Review | |
| Psychiatric effects of cannabis | 2001 | Review | |
| Beyond THC: The New Generation of Cannabinoid Designer Drugs | 2011 | Review | |
| Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug | 2006 | Review |
Citations in the library
Cited by 11
- Cannabis increases susceptibility to false memory Proceedings of the National Academy of Sciences February 10, 2020
- Functional brain connectomes reflect acute and chronic cannabis use Scientific Reports February 14, 2022
- A relação entre o uso da cannabis e o despertar de psicoses Revista Brasileira Multidisciplinar 2020
- Longitudinal Neurocognitive Trajectories in a Large Cohort of Youth Who Use Cannabis: Combining Self-Report and Toxicology. bioRxiv : the preprint server for biology March 6, 2026
- Cognitive performance recovery following marijuana cessation in NCAA division I athletes. Frontiers in Sports and Active Living 2026
and 6 more in the library
Cites 15
- Attenuated frontal and sensory inputs to the basal ganglia in cannabis users Addiction Biology March 3, 2016
- Acute and Chronic Effects of Cannabinoids on Human Cognition-A Systematic Review. Biological Psychiatry April 1, 2016
- The effects of cannabis on memory function in users with and without a psychotic disorder: findings from a combined meta-analysis. Psychological Medicine January 2016
- Cannabis, cigarettes, and their co-occurring use: disentangling differences in default mode network functional connectivity Drug and Alcohol Dependence June 10, 2015
- Permanent suppression of cortical oscillations in mice after adolescent exposure to cannabinoids: receptor mechanisms. Neuropharmacology November 2014
and 10 more in the library