Rewarding and reinforcing effects of 4-chloro-2,5-dimethoxyamphetamine and AH-7921 in rodents.
Hye Jin Cha, Seo Young Jeon, Hwa Jin Jang, Jisoon Shin, Young-Hoon Kim, Soo Kyung Suh
Neuroscience Letters May 29, 2018 DOI: 10.1016/j.neulet.2018.04.009 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal behavioral study Peer reviewed |
|---|---|
| Population | Mice (conditioned place preference) and rats (self-administration) |
| Interventions | 4-Chloro-2 5-dimethoxyamphetamine (DOC) AH-7921 |
| Dose | 0.3 mg/kg (CPP); 0.01 mg/(kg·infusion) (self-administration) |
| Measures | Conditioned place preference (CPP), self-administration (SA) |
| Keywords | 4-chloro-2,5-dimethoxyamphetamine Ah-7921 Conditioned place preference Dependence liability New psychoactive substances Self-administration |
| Key points | DOC and AH-7921 each increased drug-paired compartment preference in mice at 0.3 mg/kg and increased active-lever responses in rats at 0.01 mg/(kg·infusion), suggesting both compounds may have rewarding and reinforcing effects. The authors note that further studies are needed to confirm reinforcing effects across broader dose ranges and schedules. |
Abstract
New psychoactive substances (NPSs), i.e., newly designed substances with chemical residues that are slightly different from those of known psychoactive substances, have been emerging since the late 2000s, and social problems related to the use of these substances are increasing globally. Two such NPSs are 4-chloro-2,5-dimethoxyamphetamine (DOC), a psychedelic substance that is structurally related to amphetamine, and AH-7921, an opioid analgesic that is used for recreational purposes and has a potency similar to that of morphine. Currently, scientific evidence for the dependence liability or toxicity of NPSs is lacking. Therefore, in this study, we performed animal behavioral tests to evaluate the dependence liability of DOC and AH-7921. The rewarding and reinforcing effects of DOC and AH-7921 were evaluated using the conditioned place preference (CPP) paradigm in mice and the self-administration (SA) procedure in rats. Both DOC and AH-7921 increased the preference for the drug-paired compartment in the CPP test at a dose of 0.3 mg/kg and increased the number of responses to the active lever in the SA test at 0.01 mg/(kg·infusion). Collectively, the data suggest that DOC and AH-7921 may have both rewarding and reinforcing effects. Further studies are needed to confirm the reinforcing effects in broader dose ranges with various schedules.
Citations in the library
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