Rewarding and Reinforcing Effects of 25H-NBOMe in Rodents
Cheolmin Jo, Hyejin Joo, Dong-Hyun Youn, Jin Mook Kim, Young-Ki Hong, Na Young Lim, Kwan Soo Kim, Su-Jeong Park, Sun-Ok Choi
Brain Sciences November 2, 2022 DOI: 10.3390/brainsci12111490 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preclinical animal study Peer reviewed |
|---|---|
| Population | Mice and rats |
| Intervention | 25H-NBOMe |
| Dose | 0.1 mg/kg, 0.5 mg/kg, 0.01 mg/kg, 10 mg/kg |
| Measures | conditioned place preference (CPP), self-administration (SA), in vivo microdialysis, locomotor activity test |
| Key points | 25H-NBOMe increased locomotor activity in mice, produced conditioned place preference at 0.1 and 0.5 mg/kg, and increased self-administration infusions and active lever presses at 0.01 mg/kg. Microdialysis in rats showed increased dopamine levels at 10 mg/kg, suggesting rewarding and reinforcing effects. |
Abstract
The drug 25H-NBOMe is a new psychoactive substance (NPS). The use of these substances is likely to pose a threat to public health because they elicit effects similar to those of known psychoactive substances with similar chemical structures. However, data regarding the abuse potential of 25H-NBOMe are lacking. Here, we evaluated the abuse liability of 25H-NBOMe in rodents. The rewarding and reinforcing effects were evaluated through conditioned place preference (CPP) and self-administration (SA) tests after administration of 25H-NBOMe. To investigate the effects of 25H-NBOMe on the central nervous system, we determined the changes in dopamine levels by in vivo microdialysis. In the locomotor activity test, 25H-NBOme significantly increased locomotor activity in mice. In the place conditioning test, the 25H-NBOMe (0.1 and 0.5 mg/kg) groups showed a significantly increase in CPP in mice. In the SA test, the 25H-NBOMe (0.01 mg/kg) administered group showed a significant increased number of infusions and active lever presses. In microdialysis, the 25H-NBOMe (10 mg/kg) administered group was significantly increased in rats.
Citations in the library
Cited by 7
- Psychedelics: A review of their effects on recalled aversive memories and fear/anxiety expression in rodents Neuroscience & Biobehavioral Reviews September 20, 2024
- 25X-NBOMe compounds - chemistry, pharmacology and toxicology. A comprehensive review. Critical Reviews in Toxicology 2023
- Acute Effects of the Psychedelic Phenethylamine 25I-NBOMe in C57BL/6J Male Mice. International Journal of Molecular Sciences March 20, 2025
- The novel psychoactive substance 25E-NBOMe induces reward-related behaviors via dopamine D1 receptor signaling in male rodents Archives of Pharmacal Research April 1, 2024
- Toxicodynamic insights of 2C and NBOMe drugs - Is there abuse potential? Toxicology Reports June 1, 2025
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