Opposite Cannabis-Cognition Associations in Psychotic Patients Depending on Family History.
Ana González-Pinto, Itxaso González-Ortega, Susana Alberich, Sonia Ruiz de Azúa, Miguel Bernardo, Miquel Bioque, Bibiana Cabrera, Iluminada Corripio, Celso Arango, António Lobo, Ana M Sánchez-Torres, Manuel J Cuesta, PEPs Group
PLoS One November 11, 2017 DOI: 10.1371/journal.pone.0160949 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Sample size | 505 |
| Population | First-episode psychosis patients and controls |
| Topics | Cannabis |
| Key findings | Cannabis use was associated with worse working memory regardless of family history. In verbal memory, executive function, and global cognition, cannabis use was associated with worse performance in patients without a family history of psychosis but better performance in those with a family history, suggesting an interaction between cannabis use and familial psychosis. |
Abstract
The objective of this study is to investigate cognitive performance in a first-episode psychosis sample, when stratifying the interaction by cannabis use and familial or non-familial psychosis. Hierarchical-regression models were used to analyse this association in a sample of 268 first-episode psychosis patients and 237 controls. We found that cannabis use was associated with worse working memory, regardless of family history. However, cannabis use was clearly associated with worse cognitive performance in patients with no family history of psychosis, in cognitive domains including verbal memory, executive function and global cognitive index, whereas cannabis users with a family history of psychosis performed better in these domains. The main finding of the study is that there is an interaction between cannabis use and a family history of psychosis in the areas of verbal memory, executive function and global cognition: that is, cannabis use is associated with a better performance in patients with a family history of psychosis and a worse performance in those with no family history of psychosis. In order to confirm this hypothesis, future research should explore the actual expression of the endocannabinoid system in patients with and without a family history of psychosis.
Comparable studies
Other observational and cohort studies on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| High-potency cannabis and the risk of psychosis People with first episode of psychosis and healthy controls from the local population | 2009 | Case-control study | n = 454 |
| Ayahuasca-Assisted Therapy for Addiction: Results from a Preliminary Observational Study in Canada Rural aboriginal population | 2013 | Observational study | |
| Impaired cognitive performance in drug free users of recreational ecstasy (MDMA) Otherwise healthy young people | 2000 | Observational | |
| Continued cannabis use and risk of incidence and persistence of psychotic symptoms: 10 year follow-up cohort study Individuals from the general population in Germany aged 14-24 at baseline | 2011 | Observational cohort | n = 1,923 |
| Cannabis-induced psychosis and subsequent schizophrenia-spectrum disorders: follow-up study of 535 incident cases Patients treated for cannabis-induced psychotic symptoms in Denmark between 1994 and... | 2005 | Observational cohort | n = 535 |
Citations in the library
Cited by 10
- Poor medication adherence and risk of relapse associated with continued cannabis use in patients with first-episode psychosis: a prospective analysis The Lancet Psychiatry July 10, 2017
- Cannabis use and nonuse in patients with first-episode psychosis: A systematic review and meta-analysis of studies comparing neurocognitive functioning European Psychiatry 2020
- Premorbid Adjustment and IQ in Patients With First-Episode Psychosis: A Multisite Case-Control Study of Their Relationship With Cannabis Use Schizophrenia Bulletin July 2, 2019
- Anxiety, depression-like behaviors and biochemistry disorders induced by cannabis extract in female mice Saudi Journal of Biological Sciences September 1, 2021
- Cannabis, esquizofrenia y cognición, aportes de la conectividad cerebral Adicciones February 6, 2020
and 5 more in the library
Cites 6
- The Impact of Cannabis Use on Cognitive Functioning in Patients With Schizophrenia: A Meta-analysis of Existing Findings and New Data in a First-Episode Sample Schizophrenia Bulletin July 25, 2010
- Shared Predisposition in the Association Between Cannabis Use and Subcortical Brain Structure. JAMA Psychiatry October 2015
- Effects of Endocannabinoid System Modulation on Cognitive and Emotional Behavior Frontiers in Behavioral Neuroscience July 22, 2011
- Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up. Archives of General Psychiatry February 2011
- Cannabis and First-Episode Psychosis: Different Long-term Outcomes Depending on Continued or Discontinued Use Schizophrenia Bulletin November 13, 2009
and 1 more in the library