Anxiety, depression-like behaviors and biochemistry disorders induced by cannabis extract in female mice
Atheer M. Mohammed, Ibrahim A. Khardali, Magbool E. Oraiby, Abdulrahman F. Hakami, Emad S. Shaheen, Ibrahim M. Ageel, Eyas H. Abutawil, Gasem Mohammad Abu-Taweel
Saudi Journal of Biological Sciences September 1, 2021 DOI: 10.1016/j.sjbs.2021.08.085 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Sample size | 40 |
| Population | Healthy female mice |
| Intervention | Cannabis extract |
| Dose | 1 and 2 mg/kg |
| Duration | 14 days |
| Measures | Light-dark chamber test, forced swimming test, tail suspension test, plus maze test, open field test |
| Topics | Anxiety Cannabis Depression |
| Keywords | Tbars Depression economics Open field Corticosterone Physiology Endocrinology Lipid peroxidation Oxidative stress |
| Citations | 7 |
| Key findings | Cannabis extract at 1 and 2 mg/kg significantly increased anxiety and depressive behaviors in female mice compared to control. It also reduced DA, 5-HT, AChE, GSH, GST, CAT, and SOD while raising TBARS, corticosterone, and cortisol. |
Abstract
Cannabis is an annual herbaceous plant sometimes grown for decoration and used as bird food that looks like flax. The study wanted to determine if a Cannabis extract may have an effect on how anxious and depressed the female mice behaved. forty healthy female mice were divided into four groups. Tap water was administered to the first group (control). Ethanol was administered to second group (positive control). The third and four groups were given 1 and 2 mg/kg cannabis extract respectively. Treatment continued for 14 days. After therapy, the light-dark chamber, forced swimming, tail suspension, plus lamb and open field tests were done to assess anxiety and depressive behavior. The results indicated that the anxiety and depression were increased in treated females significantly compared to control. Biochemical results showed that DA,5-HT, AChE, GSH, GST, CAT and SOD were decreased while TBARS, corticosterone and cortisol were increased. In conclusion, cannabis effects this kind of females' behavior but the mechanisms are not clear yet. We need more researches on this trend.
Comparable studies
Other preclinical and animal studies on cannabis for anxiety, most cited first.