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Novel Tetrahydropyridinyl-6,6-Bicyclic Compounds as 5‑HT2A Receptor Agonists for Treating Depression, Anxiety, Substance Abuse, and Headaches.

Ram W. Sabnis, Anika R. Sabnis

ACS Medicinal Chemistry Letters August 13, 2026 DOI: 10.1021/acsmedchemlett.6c00430 (opens in new tab)

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AI-extracted from the abstract
Characteristics Peer reviewed
Topics Anxiety Depression Serotonin

Abstract

Provided herein are novel tetrahydropyridinyl-6,6-bicyclic compounds as 5-HT2A receptor agonists, pharmaceutical compositions, use of such compounds in treating depression, anxiety, substance abuse and headaches, and processes for preparing such compounds.

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