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Novel 5,6-Bicyclic Compounds as 5-HT2A Receptor Agonists for Treating Depression, Anxiety, Substance Abuse, and Headaches

Ram W. Sabnis, Anika R. Sabnis

ACS Medicinal Chemistry Letters June 3, 2026 DOI: 10.1021/acsmedchemlett.6c00270 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Peer reviewed
Topics Anxiety Depression Serotonin
Keywords Headaches Agonist Receptor Drug Migraine Pharmacology

Abstract

Provided herein are novel 5,6-bicyclic compounds as 5-HT2A receptor agonists, pharmaceutical compositions, use of such compounds in treating depression, anxiety, substance abuse and headaches, and processes for preparing such compounds.