Altered longitudinal trajectory of default mode network connectivity in healthy youth with subclinical depressive and posttraumatic stress symptoms.
Jake J Son, Mikki Schantell, Giorgia Picci, Yu-Ping Wang, Julia M Stephen, Vince D Calhoun, Gaelle E Doucet, Brittany K Taylor, Tony W Wilson
Developmental Cognitive Neuroscience February 17, 2023 DOI: 10.1016/j.dcn.2023.101216 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Longitudinal observational study Peer reviewed |
|---|---|
| Sample size | 190 |
| Population | Typically developing youth aged 9-15 years |
| Duration | Three annual timepoints over three years |
| Topics | Default mode network |
| Keywords | Prefrontal cortex Humans Magnetic resonance imaging Brain mapping Stress disorders, post-traumatic Adolescent Adult Child Problem behavior Development FMRI Resting-state |
| Key findings | Greater subclinical depressive symptoms were associated with decreases in default mode network connectivity over three years, while greater posttraumatic stress symptoms were associated with increases. These effects were driven by the dorsal medial prefrontal cortex subnetwork. The authors suggest the default mode network may be a nexus of clinical significance in mental health disorders. |
Abstract
The default mode network (DMN) plays a crucial role in internal self-processing, rumination, and social functions. Disruptions to DMN connectivity have been linked with early adversity and the emergence of psychopathology in adolescence and early adulthood. Herein, we investigate how subclinical psychiatric symptoms can impact DMN functional connectivity during the pubertal transition. Resting-state fMRI data were collected annually from 190 typically-developing youth (9-15 years-old) at three timepoints and within-network DMN connectivity was computed. We used latent growth curve modeling to determine how self-reported depressive and posttraumatic stress symptoms predicted rates of change in DMN connectivity over the three-year period. In the baseline model without predictors, we found no systematic changes in DMN connectivity over time. However, significant modulation emerged after adding psychopathology predictors; greater depressive symptomatology was associated with significant decreases in connectivity over time, whereas posttraumatic stress symptoms were associated with significant increases in connectivity over time. Follow-up analyses revealed that these effects were driven by connectivity changes involving the dorsal medial prefrontal cortex subnetwork. In conclusion, these data suggest that subclinical depressive and posttraumatic symptoms alter the trajectory of DMN connectivity, which may indicate that this network is a nexus of clinical significance in mental health disorders.
Comparable studies
Other observational and cohort studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| A default mode of brain function Normal adult human brain | 2001 | Observational study | |
| Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network Healthy subjects | 2008 | Observational cohort | |
| Meditation experience is associated with increased cortical thickness Participants with extensive Insight meditation experience and matched controls | 2005 | Observational cohort | n = 20 |
| Meditation experience is associated with differences in default mode network activity and connectivity Experienced meditators and matched meditation-naive controls | 2011 | Observational cohort | |
| The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis Healthy subjects | 2008 | Observational study |
Citations in the library
Cited by 2
- Chronic Cannabis users exhibit altered oscillatory dynamics and functional connectivity serving visuospatial processing. Journal of Psychopharmacology August 1, 2024
- The mediating role of default mode network during meaning-making aroused by mental simulation between stressful events and stress-related growth: a task fMRI study. Behavioral and Brain Functions July 15, 2023
Cites 11
- A default mode of brain function Proceedings of the National Academy of Sciences January 16, 2001
- The Brain's Default Mode Network Annual Review of Neuroscience May 4, 2015
- Default Mode Network Activity and Connectivity in Psychopathology Annual Review of Clinical Psychology March 29, 2012
- Patterns of Brain Activity Supporting Autobiographical Memory, Prospection, and Theory of Mind, and Their Relationship to the Default Mode Network Journal of Cognitive Neuroscience July 6, 2009
- Development of functional and structural connectivity within the default mode network in young children Neuroimage April 11, 2010
and 6 more in the library