Mindfulness-Based Cognitive Therapy in Major Depressive Disorder: A Study Protocol of a Randomized Control Trial and a Case-Control Study With Electroencephalogram.
Tianran Zhang, Lanlan Wang, Yanle Bai, Wenqing Zhao, Yanru Wu, Wenhui Jiang, Qing Fan, Jianyin Qiu
Frontiers in Psychiatry 2021 DOI: 10.3389/fpsyt.2021.499633 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Clinical protocol Randomized Peer reviewed |
|---|---|
| Sample size | 105 |
| Population | 70 Chinese patients with major depressive disorder and 35 matched normal controls |
| Interventions | Mindfulness-based cognitive therapy (MBCT) selective serotonin reuptake inhibitors (SSRIs) |
| Duration | 8-week intervention with assessments at weeks 0, 2, 4, 6, and 8, and 6-month follow-up at weeks 12, 20, and 32 |
| Topics | Depression Meditation |
| Keywords | Case-control study Electroencephalogram Randomized-control trial |
| Registration | NCT03558256 |
| Key points | The protocol outlines a randomized controlled trial to test whether adding mindfulness-based cognitive therapy to selective serotonin reuptake inhibitor medication improves outcomes in major depressive disorder, alongside a case-control comparison of electroencephalogram differences between patients and healthy controls. The authors state the results will provide a positive reference for depression treatment and future research on MBCT mechanisms. |
Abstract
Background: In this report, a study protocol for a randomized control trial is presented in an attempt to explore the efficacy of mindfulness-based cognitive therapy (MBCT) for major depressive disorder (MMD), and a case-control study is conducted to find the difference in electroencephalograms (EEGs) between MMD and normal controls.
Design: Seventy Chinese patients with MMD will be chosen for random division in the MBCT group or medication group, with half of the participants receiving common medication treatment [selective serotonin reuptake inhibitors (SSRIs)] and half receiving MBCT as a supplement to the common medication treatment. All participants, namely, 70 MMD cases and 35 matched normal controls, will be tested by a range of scales and EEG at baseline (week 0), mid-intervention (weeks 2, 4, and 6), post-intervention (week 8), and 6-months follow-up (weeks 12, 20, and 32).
Discussion: The findings of this study will provide a positive reference for the treatment of depression and future research on MBCT treatment mechanism.
Trial Registration: NCT03558256. Registered: June 13, 2018-retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03558256.
Citations in the library
Cites 8
- Mindfulness-Based Cognitive Therapy for Depression: A New Approach to Preventing Relapse Psychotherapy Research March 1, 2003
- Mental Training Affects Distribution of Limited Brain Resources PLoS Biology May 4, 2007
- Meditation, mindfulness and executive control: the importance of emotional acceptance and brain-based performance monitoring. Social Cognitive and Affective Neuroscience April 15, 2012
- The effect of mindfulness-based cognitive therapy for prevention of relapse in recurrent major depressive disorder: a systematic review and meta-analysis. Clinical Psychology Review May 15, 2011
- Mindfulness-based cognitive therapy vs cognitive behaviour therapy as a treatment for non-melancholic depression. Journal of Affective Disorders November 20, 2010
and 3 more in the library