When mood and time align: nasal esketamine reduces lived time disturbances in treatment-resistant depression.
Stefan Jerotić, Milica Nestorovic, Janko Nešić, Anastazja Szuła, Marcin Moskalewicz
International journal of psychiatry in clinical practice July 10, 2025 DOI: 10.1080/13651501.2025.2528692 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 2 |
| Population | Two male patients of Serbian ethnicity with treatment-resistant depression |
| Intervention | nasal esketamine |
| Duration | At least 4 weeks |
| Topics | Depression Esketamine Philosophy of mind |
| Keywords | Depression treatment Trd Antidepressant therapy Psychiatric intervention Mental health recovery Time perception Subjective time Temporal experience Sense of time Chronesthesia Clinical assessment Treatment monitoring Outcome measures Early indicators Diagnostic tools Patient evaluation |
| Citations | 3 |
| Key findings | TATE scores reached general population levels at week 4, one week prior to treatment response indicated by MADRS in one patient. |
Abstract
These two cases highlight the utility of a focused, structured clinical phenomenological interview in measuring treatment effectiveness in subjective experience. Two male patients, aged 35 and 27, of Serbian ethnicity with treatment-resistant depression were treated with nasal esketamine, with clinical progress monitored using both the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Transdiagnostic Assessment of Temporal Experience (TATE), a structured instrument assessing the patient's felt sense of time. Notably, TATE scores in the first case reached general population levels at week 4, one week prior to the treatment response, as indicated by MADRS. These findings underscore the value of phenomenological assessments in complementing traditional depression scales to capture nuanced improvements during treatment.