The functional neuroanatomy of brain cannabinoid receptors.
C S Breivogel, S R Childers
Neurobiology of Disease December 1998 DOI: 10.1006/nbdi.1998.0229 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Key findings | The authors propose that THC's effects on movement, memory, pain, endocrine regulation, thermoregulation, sensory perception, cognition, and mood are mediated by CB1 and CB2 receptors, and that these effects track the regional distribution of cannabinoid receptors and their activation of specific G-protein-mediated signaling systems across brain regions. |
Abstract
The effects of the primary psychoactive constituent of marijuana, delta 9-tetrahydrocannabinol, are mediated by cannabinoid receptors, CB1 and CB2. The CB1 receptors display a unique central nervous system (CNS) distribution and are present in mammalian brain at higher levels than most other known G-protein-coupled receptors. The highest levels occur in several areas involved in motor control and hippocampus. Cannabinoid effects on CNS activities, including movement, memory, nociception, endocrine regulation, thermoregulation, sensory perception, cognitive functions, and mood, correlate with the regional distribution of cannabinoid receptors and their activation of specific G-protein-mediated signal transduction systems in various brain regions.
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- Targeting the Endocannabinoid System in Psychiatric Illness. Journal of Clinical Psychopharmacology December 2016
- The effects of beta-arrestin1 deletion on acute cannabinoid activity, brain cannabinoid receptors and tolerance to cannabinoids in mice. Journal of receptor and signal transduction research February 2015
- Separate and combined effects of the GABA reuptake inhibitor tiagabine and Δ9-THC in humans discriminating Δ9-THC. Drug and Alcohol Dependence April 1, 2012
and 8 more in the library
Cites 3
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