Unraveling Psychedelic Responses: Targeted Protein Degradation and Genetic Diversity
ACS Medicinal Chemistry Letters July 11, 2023 DOI: 10.1021/acsmedchemlett.3c00269 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Commentary Peer reviewed |
|---|---|
| Key points | Proposes that integrating targeted protein degradation technologies into psychedelic research could help address genetic variability in treatment response, potentially leading to personalized treatments and improved patient outcomes. The authors acknowledge implementation challenges and suggest strategies to address them, drawing on lessons from COVID-19 research on genetic variability. |
Abstract
This Viewpoint discusses the intersection of targeted protein degradation (TPD) technologies and psychedelic research. The resurgence in interest in psychedelics for treating mental disorders and the known genetic variability in responses require new strategies. TPD technologies might address this variability, modulating protein expressions based on genetic profiles. The discussion includes potential challenges in implementing TPD technologies in psychedelic research and potential strategies to address these issues. It considers lessons from COVID-19 research on genetic variability, proposing integration of TPD technologies into psychedelic research as a promising field despite these challenges, possibly leading to personalized treatments and improved patient outcomes.
Citations in the library
Cites 7
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- Psychedelics as Transformative Therapeutics. American Journal of Psychiatry May 1, 2023
- Psychedelic-induced mystical experiences: An interdisciplinary discussion and critique Frontiers in Psychiatry April 5, 2023
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and 2 more in the library