Skip to content

The phenomenology of psilocybin: transformative insights for research and clinical practice

Antonio Metastasio, Elisabeth Prevete, Sofia Venturini, Andrea Garofalo, Beatrice Cecconello, Nicola De Pisapia, Ornella Corazza

Frontiers in Psychology April 25, 2025 DOI: 10.3389/fpsyg.2025.1455902 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Qualitative study using interpretative phenomenological analysis and dynamic analysis Peer reviewed
Sample size 10
Population Healthy adults who had experienced psilocybin without other substances
Intervention Psilocybin
Topics Philosophy of mind Psilocybin
Keywords Lived experiences Psychopathology Psylocibin Qualitative approach Psychedelics hallucinogens Entheogens Phenomenology lived experience First-person experience Subjective experience Personal transformation self-development Psychological growth Behavioral
Citations 8
Key findings Psilocybin experiences were associated with enhanced emotional and interpersonal sensitivity, increased empathy, deeper connection to others, and lasting insights into life and values, along with profound behavioral and attitudinal changes.

Abstract

Introduction: Considering the increasing evidence supporting psilocybin’s efficacy in therapeutic settings, it is essential to deepen our understanding of its subjective meanings and effects to enhance its integration into psychotherapy. Current knowledge is primarily based on psychometric assessments or unstructured personal reports, leaving a gap in the qualitative analysis of subjective psychedelic experiences and the resulting changes.

Objective: This study aimed to describe the subjective psychedelic experience with psilocybin in a structured, objective, and non-judgmental way ( Epoche ), while exploring its potential clinical applications.

Methods: A phenomenological qualitative approach, integrating interpretative phenomenological analysis (IPA) and the dynamic analysis (PHD) method, was used to analyze self-reported psilocybin experiences. Participants who met the inclusion criteria of being healthy adults and who had experienced psilocybin without any other substances were recruited through convenience sampling. Semi-structured interviews explored dimensions such as emotions, bodily sensations, perception of time and space, relationships, values, and enduring transformation. Data were analyzed using thematic coding.

Results: Ten interviews were carried out with voluntary participants. All the interviewees reported enhanced emotional and interpersonal sensitivity, increased empathy, a deeper connection to others, and a heightened ability to resolve personal issues as well as long-lasting insights into their lives and values. Participants also showed profound changes in behavior, attitudes, and interests, indicative of the potential for psilocybin to catalyze significant personal growth and development.

Conclusion: This study highlights the transformative potential of psilocybin experiences and their relevance to psychotherapeutic practices. By employing phenomenological methods, we offer a structured understanding of these states, which could be used in future to provide guidance for their integration into therapy by giving a better insight into psychedelic experience.

Comparable studies

Other qualitative studies on psilocybin, most cited first.

Study Year Design Participants
Patients’ Accounts of Increased “Connectedness” and “Acceptance” After Psilocybin for Treatment-Resistant Depression Patients with treatment-resistant depression enrolled in an open-label trial of psilocybin 2017 Qualitative study n = 20
Patient Experiences of Psilocybin-Assisted Psychotherapy: An Interpretative Phenomenological Analysis Adults aged 22 to 69 with clinically elevated anxiety associated with a cancer diagnosis 2017 Qualitative study n = 13
Psychedelic therapy for smoking cessation: Qualitative analysis of participant accounts Participants who completed a psilocybin-facilitated smoking cessation pilot study 2018 Qualitative follow-up study using semi-structured interviews and thematic analysis n = 12
Response of cluster headache to psilocybin and LSD Cluster headache patients who used psilocybin or LSD 2006 Qualitative study n = 53
Cancer at the Dinner Table: Experiences of Psilocybin-Assisted Psychotherapy for the Treatment of Cancer-Related Distress Adult participants with clinically elevated anxiety associated with a cancer diagnosis 2017 Qualitative study using interpretative phenomenological analysis n = 13

Citations in the library

Cited by 7

and 2 more in the library

Cites 35

and 30 more in the library

Explore topics