The phenomenology of psilocybin: transformative insights for research and clinical practice
Antonio Metastasio, Elisabeth Prevete, Sofia Venturini, Andrea Garofalo, Beatrice Cecconello, Nicola De Pisapia, Ornella Corazza
Frontiers in Psychology April 25, 2025 DOI: 10.3389/fpsyg.2025.1455902 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Qualitative study using interpretative phenomenological analysis and dynamic analysis Peer reviewed |
|---|---|
| Sample size | 10 |
| Population | Healthy adults who had experienced psilocybin without other substances |
| Intervention | Psilocybin |
| Topics | Philosophy of mind Psilocybin |
| Keywords | Lived experiences Psychopathology Psylocibin Qualitative approach Psychedelics hallucinogens Entheogens Phenomenology lived experience First-person experience Subjective experience Personal transformation self-development Psychological growth Behavioral |
| Citations | 8 |
| Key findings | Psilocybin experiences were associated with enhanced emotional and interpersonal sensitivity, increased empathy, deeper connection to others, and lasting insights into life and values, along with profound behavioral and attitudinal changes. |
Abstract
Introduction: Considering the increasing evidence supporting psilocybin’s efficacy in therapeutic settings, it is essential to deepen our understanding of its subjective meanings and effects to enhance its integration into psychotherapy. Current knowledge is primarily based on psychometric assessments or unstructured personal reports, leaving a gap in the qualitative analysis of subjective psychedelic experiences and the resulting changes.
Objective: This study aimed to describe the subjective psychedelic experience with psilocybin in a structured, objective, and non-judgmental way ( Epoche ), while exploring its potential clinical applications.
Methods: A phenomenological qualitative approach, integrating interpretative phenomenological analysis (IPA) and the dynamic analysis (PHD) method, was used to analyze self-reported psilocybin experiences. Participants who met the inclusion criteria of being healthy adults and who had experienced psilocybin without any other substances were recruited through convenience sampling. Semi-structured interviews explored dimensions such as emotions, bodily sensations, perception of time and space, relationships, values, and enduring transformation. Data were analyzed using thematic coding.
Results: Ten interviews were carried out with voluntary participants. All the interviewees reported enhanced emotional and interpersonal sensitivity, increased empathy, a deeper connection to others, and a heightened ability to resolve personal issues as well as long-lasting insights into their lives and values. Participants also showed profound changes in behavior, attitudes, and interests, indicative of the potential for psilocybin to catalyze significant personal growth and development.
Conclusion: This study highlights the transformative potential of psilocybin experiences and their relevance to psychotherapeutic practices. By employing phenomenological methods, we offer a structured understanding of these states, which could be used in future to provide guidance for their integration into therapy by giving a better insight into psychedelic experience.
Comparable studies
Other qualitative studies on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Patients’ Accounts of Increased “Connectedness” and “Acceptance” After Psilocybin for Treatment-Resistant Depression Patients with treatment-resistant depression enrolled in an open-label trial of psilocybin | 2017 | Qualitative study | n = 20 |
| Patient Experiences of Psilocybin-Assisted Psychotherapy: An Interpretative Phenomenological Analysis Adults aged 22 to 69 with clinically elevated anxiety associated with a cancer diagnosis | 2017 | Qualitative study | n = 13 |
| Psychedelic therapy for smoking cessation: Qualitative analysis of participant accounts Participants who completed a psilocybin-facilitated smoking cessation pilot study | 2018 | Qualitative follow-up study using semi-structured interviews and thematic analysis | n = 12 |
| Response of cluster headache to psilocybin and LSD Cluster headache patients who used psilocybin or LSD | 2006 | Qualitative study | n = 53 |
| Cancer at the Dinner Table: Experiences of Psilocybin-Assisted Psychotherapy for the Treatment of Cancer-Related Distress Adult participants with clinically elevated anxiety associated with a cancer diagnosis | 2017 | Qualitative study using interpretative phenomenological analysis | n = 13 |
Citations in the library
Cited by 7
- Why psychedelic-assisted therapy studies in eating disorders risk missing the mark on outcomes: a phenomenological psychopathology perspective. Journal of Eating Disorders September 2, 2025
- The intersection between psychedelics and schizophrenia spectrum disorders: Reevaluating risk and therapeutic potential. Journal of Psychopharmacology June 25, 2026
- 5-HT1A receptor blockade potentiates the subjective effects of DMT. Journal of Psychopharmacology May 2, 2026
- Facing trauma under the influence of psychedelics: A phenomenological study with Nova rave survivors. Journal of Psychopharmacology May 1, 2026
- Hallucinogenic Therapy in Alzheimer's Disease targeting Mitochondria-Associated Membranes. Neuroscience April 6, 2026
and 2 more in the library
Cites 35
- Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial Journal of Psychopharmacology November 30, 2016
- Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance Psychopharmacology July 7, 2006
- Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study. The Lancet Psychiatry May 17, 2016
- Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder JAMA Psychiatry November 4, 2020
- Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study Journal of Psychopharmacology January 13, 2015
and 30 more in the library