Tackling the growing burden of nitrous oxide-induced public health harms.
Safiya A Zaloum, Devan Mair, Álvaro París, Laura J Smith, Marta Patyjewicz, Barbara L Onen, Alastair J. Noyce
The Lancet Public Health February 1, 2025 DOI: 10.1016/s2468-2667(24)00298-6 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Commentary Peer reviewed |
|---|---|
| Key points | Argues that rising recreational nitrous oxide use has brought increasing health harms, particularly nitrous oxide-induced myeloneuropathy, and that laws criminalising users may exacerbate harm by deterring health-care seeking. Contends that education about preventable harm and tighter supplier regulation are essential to mitigate these harms. |
Abstract
Nitrous oxide has been increasing in popularity as a recreational drug in the past decade, and with this an increase in health harms related to nitrous oxide use, particularly nitrous oxide-induced myeloneuropathy. In response, governments in many countries have adopted new laws that either target the end user, by criminalising possession, or target suppliers. The effect of these measures remains to be seen, but the potential to exacerbate harm by targeting the user and thus affecting health-care-seeking behaviour is a concern. Education around the preventable harm from recreational use of nitrous oxide and tightening regulations on suppliers are essential in mitigating the increase in nitrous oxide-related health harms.
Citations in the library
Cited by 11
- Acute Psychosis and Dissociative Syndrome Following Binge Recreational Nitrous Oxide Use: A Case Report Cureus September 17, 2026
- Ketamine: reclassification alone will not reduce harms BMJ February 3, 2026
- A Diagnostic Challenge in Polysubstance Use: Nitrous Oxide–induced Neurological Toxicity Masked by Alcohol Withdrawal—A Case Report Canadian Journal of Addiction August 7, 2026
- Nitrous Oxide Misuse JAMA May 26, 2026
- Chronic Nitrous Oxide Exposure Disrupts Metabolism in Mice: A Plasma Untargeted Metabolomics Study Metabolites May 1, 2026
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Cites 8
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- Recreational use of nitrous oxide causes seizure, pneumothorax, pneumomediastinum, and pneumopericardium: nitrous oxide and its harm, a case report Upsala Journal of Medical Sciences December 8, 2023
- Nitrous oxide-induced myeloneuropathy: a case series Journal of Neurology, Neurosurgery, and Psychiatry May 30, 2023
- Nitrous oxide-induced subacute combined degeneration of the cord: diagnosis and treatment Practical Neurology February 22, 2023
- Problematic Use of Nitrous Oxide by Young Moroccan-Dutch Adults. International Journal of Environmental Research and Public Health May 23, 2021
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