Efektivitas Mindfulness terhadap Penurunan Gejala Preeklampsia pada Ibu Hamil Trimester III: Systematic Literature Review
Nasrawati Nasrawati, Sri Yuliatin, Siti Aisa, H. Halijah
Jurnal Ners May 15, 2026 DOI: 10.31004/jn.v10i3.57658 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review Peer reviewed |
|---|---|
| Sample size | 4,128 |
| Population | Third-trimester pregnant women |
| Interventions | Mindfulness MBSR MBCT |
| Duration | At least 6 weeks with a frequency of at least 2 times per week |
| Topics | Meditation |
| Key findings | Mindfulness interventions significantly reduced systolic blood pressure by 5.4–10.1 mmHg, diastolic blood pressure by 3.2–6.8 mmHg, and anxiety scores (SMD −0.52; 95% CI −0.71 to −0.33) in third-trimester pregnant women, with anti-inflammatory effects shown by reductions in IL-6 and CRP. The authors conclude mindfulness is a promising adjunctive intervention for preeclampsia management, but call for multicenter randomized trials measuring angiogenic biomarkers (sFlt-1/PlGF). |
Abstract
Preeklampsia menyumbang 27,1% kematian ibu di Indonesia. Faktor psikologis, khususnya stres kronik dan kecemasan antenatal, berkontribusi signifikan terhadap patogenesis melalui aktivasi sumbu HPA dan disfungsi endotel. Mindfulness sebagai intervensi non-farmakologis berpotensi menargetkan jalur psikofisiologis ini. Mensintesis secara sistematis evidence mengenai efektivitas intervensi mindfulness terhadap penurunan gejala preeklampsia (tekanan darah, proteinuria, biomarker inflamasi) pada ibu hamil trimester III. Systematic literature review mengikuti panduan PRISMA 2020. Pencarian dilakukan di PubMed, Scopus, Cochrane Library, Google Scholar, dan CINAHL (2013–2025). Kriteria inklusi: studi RCT, quasi-eksperimental, dan systematic review pada ibu hamil trimester III dengan intervensi mindfulness (MBSR, MBCT, meditasi pernapasan) yang mengukur parameter preeklampsia. Dari 489 rekam yang teridentifikasi, 41 studi memenuhi kriteria inklusi (N=4.128 ibu hamil, 12 negara, 2013–2025). Mindfulness secara signifikan menurunkan tekanan darah sistolik (rata-rata penurunan 5,4–10,1 mmHg; p<0,05), diastolik (3,2–6,8 mmHg), dan skor kecemasan (SMD −0,52; 95%CI −0,71 hingga −0,33). Efek anti-inflamasi ditunjukkan melalui penurunan IL-6 dan CRP. Durasi ≥6 minggu dengan frekuensi minimal 2×/minggu menunjukkan efek optimal. Mindfulness merupakan intervensi adjuvan yang menjanjikan dalam manajemen preeklampsia, dengan efek bermakna pada parameter tekanan darah dan psikologis. Diperlukan RCT multisenter dengan pengukuran biomarker angiogenik (sFlt-1/PlGF) untuk memperkuat bukti.
Comparable studies
Other systematic reviews and meta-analyses on meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Meditation Programs for Psychological Stress and Well-being Diverse adult clinical populations | 2014 | Meta-analysis | n = 3,515 |
| Mindfulness-Based Stress Reduction for Stress Management in Healthy People: A Review and Meta-Analysis Healthy subjects | 2009 | Systematic review and meta-analysis | |
| The psychological effects of meditation: A meta-analysis. Nonclinical groups of adult meditators | 2012 | Meta-analysis | n = 163 |
| Efficacy of Mindfulness-Based Cognitive Therapy in Prevention of Depressive Relapse Adults with recurrent depression in full or partial remission | 2016 | Meta-analysis of individual patient data from randomized controlled trials | n = 1,258 |
| Mindfulness‐Based Stress Reduction and Mindfulness‐Based Cognitive Therapy – a systematic review of randomized controlled trials | 2011 | Systematic review |