Biochemical and behavioral effects of sigma and PCP ligands
Patricia C. Contreras, Margarita L. Contreras, Thomas L. O'donohue, Cecelia C. Lair
Study at a glance
AI-extracted from the abstract| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | 1 |
| Key points | Two distinct binding sites for PCP and sigma ligands were characterized in rat tissue, differing in drug selectivity and potency. Both MK-801 (PCP-preferring) and 1,3-di-O-tolylguanidine (sigma-preferring) induced sniffing, rearing, circling, backpedaling, and weaving, suggesting both receptors mediate stereotyped behavior and ataxia. |
Abstract
Abstract The purpose of this study was to examine the binding and behavioral effects mediated by PCP and sigma receptors in the rat. From the radioreceptor assays, it was possible to characterize two binding sites that interact with PCP and sigma ligands. The two sites, a PCP and sigma receptor, could be differentiated based on drug selectivity and potency. In the behavioral assays, MK‐801, which bound preferentially to the PCP receptor, and 1,3‐di‐O‐tolylguanidine, which bound preferentially to the sigma receptor, induced sniffing, rearing, circling, backpedaling, and weaving behavior. These results indicate that there are distinct PCP and sigma receptors that are both involved in mediating stereotyped behavior and ataxia in the rat.
Citations in the library
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