Phencyclidine receptors and N-methyl-D-aspartate antagonism: electrophysiologic data correlates with known behaviours.
D Martin, D Lodge
Pharmacology, Biochemistry, and Behavior October 1, 1988 DOI: 10.1016/0091-3057(88)90346-2 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Laboratory study Peer reviewed |
|---|---|
| Population | Cortical wedges and isolated frog spinal cords |
| Intervention | phencyclidine (PCP) and sigma receptor ligands |
| Key points | Phencyclidine receptor ligands, but not sigma or kappa ligands, are selective NMDA antagonists, and their potencies correlate with PCP receptor binding and discrimination studies. |
Abstract
Using cortical wedges and isolated frog spinal cords, the potency of a series of psychoactive phencyclidine (PCP) and sigma receptor ligands as antagonists of N-methyl-D-aspartate (NMDA) has been compared with their potency in neurochemical and behavioural studies. Phencyclidine receptor, but not sigma or kappa, ligands were selective antagonists of NMDA on both preparations. Combination studies suggested that dissociative anaesthetics and sigma benzomorphans act at the same site. The relative potencies of the drugs as NMDA antagonists correlated well with their potency in PCP receptor binding studies in vitro and in PCP discrimination studies in vivo.
Citations in the library
Cited by 4
- Ketamine and phencyclidine: the good, the bad and the unexpected. British Journal of Pharmacology September 2015
- The role of the NMDA synapse in general anesthesia. Toxicology Letters November 23, 1998
- An information processing theory of anaesthesia. Neuropsychologia September 1995
- A rapid method for evaluating the behavioral effects of phencyclidine-like dissociative anesthetics in mice. Psychopharmacology 1991
Cites 5
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