Tolerance and cross-tolerance to 3,4-methylenedioxymethamphetamine (MDMA), methamphetamine and methylenedioxyamphetamine.
James P Zacny, R M Virus, William L. Woolverton
Pharmacology, Biochemistry, and Behavior March 1990 DOI: 10.1016/0091-3057(90)90301-w (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | MDMA Methamphetamine MDA |
| Dose | MDMA 0.62-20.0 mg/kg; methamphetamine 0.62-5.0 mg/kg; MDA 0.62-5.0 mg/kg; repeated daily MDMA 2.5-5.0 mg/kg |
| Topics | MDMA |
| Key findings | Repeated daily MDMA administration produced tolerance to MDMA's suppression of milk intake in rats, indicated by a rightward shift in the dose-response curve. Cross-tolerance to methamphetamine appeared only when MDMA was given before the drinking session, and no cross-tolerance to MDA developed in any group. |
Abstract
The effects of (+-)-3,4-methylenedioxymethamphetamine (MDMA) (0.62-20.0 mg/kg), (+)-methamphetamine (MA) (0.62-5.0 mg/kg) and (+/-)-3,4-methylenedioxyamphetamine (MDA) (0.62-5.0 mg/kg) on milk intake in rats were determined before and during a period of repeated daily administration of MDMA. Experimental sessions consisted of 15-min access to a sweetened milk solution each day, 5 days a week. After initial determination of the effects of MDMA, MA and MDA on milk intake, rats were injected daily with either MDMA (2.5-5.0 mg/kg) or saline. Two groups of rats were injected with MDMA, one group 15 min before, and the other group 15 min after the milk-drinking sessions. Two more groups of rats were injected with saline, one group 15 min before, and the other group 15 min after the sessions. During this repeated administration period the effects of MDMA, MA and MDA (injected 15 min prior to the session) were redetermined. In rats that had been injected with MDMA on a daily basis either before or after the milk-drinking sessions, the dose-response function of MDMA was shifted to the right, indicating that tolerance had developed. Cross-tolerance to MA appeared to develop only in the group of rats that had been injected with MDMA on a daily basis before the milk-drinking sessions. Cross-tolerance to MDA did not develop in any of the 4 groups of rats.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 7
- Chronic tolerance to recreational MDMA (3,4-methylenedioxymethamphetamine) or Ecstasy Journal of Psychopharmacology 2005
- The varieties of ecstatic experience: an exploration of the subjective experiences of ecstasy. Journal of Psychopharmacology September 1, 2006
- MDMA effects consistent across laboratories Psychopharmacology March 15, 2014
- MDMA and memory: the acute and chronic effects of MDMA in pigeons performing under a delayed-matching-to-sample procedure Psychopharmacology February 1, 1993
- Ecstasy, molly, MDMA: What health practitioners need to know about this common recreational drug. Disease-a-month : DM March 1, 2025
and 2 more in the library
Cites 10
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- Behavioral effects of (+-) 3,4-methylenedioxyamphetamine (MDA) and (+-) 3,4-methylenedioxymethamphetamine (MDMA) in the pigeon: interactions with noradrenergic and serotonergic systems. Psychopharmacology 1989
- Drug discrimination studies with MDMA and amphetamine. Psychopharmacology 1988
- The threshold lowering effects of MDMA (ecstasy) on brain-stimulation reward. Psychopharmacology 1988
and 5 more in the library