DOM and related 2,5-dimethoxy-4-alkylphenylisopropylamines: behavioral and serotonin receptor properties.
Richard A Glennon, D L Doot, R Young
Pharmacology, biochemistry, and behavior March 1981 DOI: 10.1016/0091-3057(81)90392-0 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal behavioral pharmacology study Peer reviewed |
|---|---|
| Population | Isolated rat fundus preparations and rats trained to discriminate 5-OMe DMT from saline |
| Interventions | DOM DOET DOPR DOBU DOTB DOAM 5-OMe DMT |
| Measures | pA2, pD2, drug discrimination generalization |
| Topics | Serotonin |
| Key points | The six 2,5-DMA derivatives had similar serotonin receptor affinities (pA2 7.02–7.22) and acted as agonists at serotonin and phenoxybenzamine-resistant tryptamine receptors. In drug-discrimination tests, DOET, DOPR, DOBU, DOTB, and DOAM produced only partial generalization from 5-OMe DMT, indicating that their stimulus properties are qualitatively dissimilar to those of 5-OMe DMT despite high 5-HT receptor affinity. |
Abstract
Using an isolated rat fundus preparation, the 4-methyl (DOM), ethyl (DOET), propyl (DOPR) butyl (DOBU), tertiary butyl (DOTB) and amyl (DOAM) derivatives of 2,5-dimethoxy-phenylisopropylamine (2,5-DMA) were found to possess quite similar serotonin receptor affinities (pA2 - 7.02-7.22). The fundus preparation could not be used to determine pD2 values because all of the compounds were found to interact in an agonistic manner both with serotonin and PRT (phenoxybenzamine resistant tryptamine) receptors. Administration of DOET, DOPR, DOBU, DOTB and DOAM to animals (rats) trained to discriminate 5-OMe DMT from saline resulted only in partial generalization. While each of these agents possesses a high 5-HT receptor affinity, and while their behavioral effects might, therefore, involve a serotonergic component, the stimulus properties of these compounds are qualitatively dissimilar to those produced by the training dose of 5-OMe DMT.